Figure 4

Regulation of Fear Behavior by Microcircuits within the Mouse Amygdala

Cheng Wei* and Wen Yao*

Published: 10 March, 2025 | Volume 9 - Issue 1 | Pages: 001-009

jnnd-aid1105-g004

Figure 4:

Dynamic activation patterns of amygdalar circuits during fear acquisition and extinction (solid lines denote activated and upregulated pathways, while dashed lines indicate inhibited pathways). Left: During fear acquisition, sensory inputs from the thalamus and cortex converge at the lateral amygdala (LA) for integration. Fear-encoding neurons in the basolateral amygdala (BA) directly excite the medial division of the central amygdala (CEM), which mediates downstream fear responses. Right: During fear extinction, extinction-specific neurons in the BLA exhibit heightened activity, projecting to both the CEM and ventral ITC neurons. The ITC, in turn, suppresses fear output from the CEM. Across both processes, the ITC serves as a critical relay for information transfer between the BLA and CeA.

Read Full Article HTML DOI: 10.29328/journal.jnnd.1001105 Cite this Article Read Full Article PDF

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