Abstract

Review Article

Bimatoprost Ophthalmic Solution (BOS) 0.3 mg w/v for 1 Open Trial of Long-term Preventive Therapy of Migraine in 3 patients with Pathophysiologic Shift from Brain to Eye

Vinod Kumar Gupta*

Published: 09 November, 2023 | Volume 7 - Issue 2 | Pages: 134-054

Known since antiquity, migraine is a complex primary disorder, an episodic painful Autonomic Nervous System (ANS) storm, generally following the stress/post-stress phase. Despite exhaustive study of neuropeptides, neurochemicals, molecules, neurogenetics, neuroimaging along with animal and human experiments over the last 50 years, the scientific basis of migraine remains unknown. Straddling eight decades from Cortical Spreading Depression (CSD) to Calcitonin-Gene Related Peptide (CGRP) and its antagonists, exponentially increasing data have failed to create a gestalt synthesis. This article lays cohesive and robust fundamental principles for the comprehension and management of migraine. The continuum between migraine and non-congestive Primary Open-Angle Glaucoma (POAG), Normal Tension Glaucoma (NTG), or Low-Tension Glaucoma (LTG) is advancing. The case of sustained remission of migraine attacks (> 75%) over 3 years - 5 years with ocular hypotensive topical Bimatoprost Ophthalmic Solution (BOS) 0.3% in an N-of-1 trial in 3 patients with refractory migraine is presented. A cause-effect-adaptive process underlies the ANS-stress/post-stress-linked biology of migraine. Vasopressin-serotonin-norepinephrine ‘homeostatic-adaptive system’ Lowers Intraocular Pressure (IOP), while enhancing anti-stress, antinociception, vasomotor, and behaviour control functions, thereby selectively decreasing algogenic neural traffic in the ophthalmic division of trigeminal nerve (V1), and, raising the threshold to develop migraine. Striking migraine headache-aborting feature of vomiting is also likely linked to a several hundred-fold increase in arginine-vasopressin secretion. Eye-cover tests and self-ocular digital displacement are essential to studying the visual aura. Real-time physical displacement of Scintillating Scotoma (SS) and floating ‘stars’ is reported. The basis of spontaneous onset and offset, self-limited duration of migraine attacks, as well as female preponderance, and age/menopause decline in prevalence, are elucidated. Intraocular implants with long-term ocular hypotensive effects, including bimatoprost, are the future of migraine management. Controlled trials are required to establish the migraine-preventive effect of topical bimatoprost, a revolutionary advance in neuroscience.

Read Full Article HTML DOI: 10.29328/journal.jnnd.1001087 Cite this Article Read Full Article PDF

Keywords:

Migraine; Psychosocial stress; ANS-dysfunction; Choroido-retinal arterial circulation; Intraocular pressure; Ocular globe; Corneoscleral envelope; Corneoscleral distention; Pan-trigeminal; Ophthalmic division of trigeminal nerve (V1); Mechanical pronociceptive neural traffic; Ocular rigidity; Tamponade; Elasticity; Spontaneous onset; Spontaneous offset; Ebstein anomaly; Congenital heart disease; Morbid obesity; Female preponderance; Age-linked prevalence

References

  1. Ashina M, Katsarava Z, Do TP, Buse DC, Pozo-Rosich P, Özge A, Krymchantowski AV, Lebedeva ER, Ravishankar K, Yu S, Sacco S, Ashina S, Younis S, Steiner TJ, Lipton RB. Migraine: epidemiology and systems of care. Lancet. 2021 Apr 17;397(10283):1485-1495. doi: 10.1016/S0140-6736(20)32160-7. Epub 2021 Mar 25. PMID: 33773613.
  2. Ashina M, Terwindt GM, Al-Karagholi MA, de Boer I, Lee MJ, Hay DL, Schulte LH, Hadjikhani N, Sinclair AJ, Ashina H, Schwedt TJ, Goadsby PJ. Migraine: disease characterisation, biomarkers, and precision medicine. Lancet. 2021 Apr 17;397(10283):1496-1504. doi: 10.1016/S0140-6736(20)32162-0. Epub 2021 Mar 25. PMID: 33773610.
  3. Ashina M, Buse DC, Ashina H, Pozo-Rosich P, Peres MFP, Lee MJ, Terwindt GM, Halker Singh R, Tassorelli C, Do TP, Mitsikostas DD, Dodick DW. Migraine: integrated approaches to clinical management and emerging treatments. Lancet. 2021 Apr 17;397(10283):1505-1518. doi: 10.1016/S0140-6736(20)32342-4. Epub 2021 Mar 25. PMID: 33773612.
  4. Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018 Jan;38(1):1-211. doi: 10.1177/0333102417738202. PMID: 29368949.
  5. Pozo-Rosich P, Lucas C, Watson DPB, Gaul C, Ramsden E, Ritter S, Martelletti P, Snellman J. Burden of Migraine in Patients With Preventive Treatment Failure Attending European Headache Specialist Centers: Real-World Evidence From the BECOME Study. Pain Ther. 2021 Dec;10(2):1691-1708. doi: 10.1007/s40122-021-00331-3. Epub 2021 Oct 13. PMID: 34643891; PMCID: PMC8586314.
  6. Gupta VK. Reader response: Potential for treatment benefit of small molecule CGRP receptor antagonist plus monoclonal antibody in migraine therapy. Neurology. 2020.
  7. Martínez-Fernández A, Rueda Vega M, Quintas S, de Toledo Heras M, Díaz de Terán J, Latorre González G, Trabajos García O, Vivancos Mora J, Gago-Veiga AB. Psychosocial repercussion of migraine: is it a stigmatized disease? Neurol Sci. 2020 Aug;41(8):2207-2213. doi: 10.1007/s10072-020-04332-6. Epub 2020 Mar 14. PMID: 32172402.
  8. Parikh SK, Young WB. Migraine: Stigma in Society. Curr Pain Headache Rep. 2019 Feb 9;23(1):8. doi: 10.1007/s11916-019-0743-7. PMID: 30739216.
  9. Vilanilam GK, Badi MK, Meschia JF. Destigmatizing Migraine. Cureus. 2018 May 30;10(5):e2711. doi: 10.7759/cureus.2711. PMID: 30065904; PMCID: PMC6066189.
  10. Lipton RB, Tepper SJ, Silberstein SD, Kudrow D, Ashina M, Reuter U, Dodick DW, Zhang F, Rippon GA, Cheng S, Mikol DD. Reversion from chronic migraine to episodic migraine following treatment with erenumab: Results of a post-hoc analysis of a randomized, 12-week, double-blind study and a 52-week, open-label extension. Cephalalgia. 2021 Jan;41(1):6-16. doi: 10.1177/0333102420973994. Epub 2020 Dec 3. PMID: 33269951; PMCID: PMC7786390.
  11. Gupta VK. Pathophysiology of migraine: an increasingly complex narrative to 2020. Fut Neurol. 2019; 14. [doi.org/10.2217/fnl-2019-0003]
  12. Rattanawong W, Rapoport A, Srikiatkhachorn A. Neurobiology of migraine progression. Neurobiol Pain. 2022 Jun 9;12:100094. doi: 10.1016/j.ynpai.2022.100094. PMID: 35720639; PMCID: PMC9204797.
  13. Rosignoli C, Ornello R, Onofri A, Caponnetto V, Grazzi L, Raggi A, Leonardi M, Sacco S. Applying a biopsychosocial model to migraine: rationale and clinical implications. J Headache Pain. 2022 Aug 11;23(1):100. doi: 10.1186/s10194-022-01471-3. Erratum in: J Headache Pain. 2022 Sep 7;23(1):116. PMID: 35953769; PMCID: PMC9367111.
  14. Su M, Yu S. Chronic migraine: A process of dysmodulation and sensitization. Mol Pain. 2018 Jan-Dec;14:1744806918767697. doi: 10.1177/1744806918767697. Epub 2018 Apr 12. PMID: 29642749; PMCID: PMC5900816.
  15. Gupta VK. CSD, BBB and MMP-9 elevations: animal experiments versus clinical phenomena in migraine. Expert Rev Neurother. 2009 Nov;9(11):1595-614. doi: 10.1586/ern.09.103. PMID: 19903020.
  16. Gupta VK. Adaptive Mechanisms in Migraine. A Comprehensive Synthesis in Evolution. Breaking the Migraine Code. VK Gupta. (Editor). New York: Nova Science Publications, New York. 2009; 1-122.
  17. Mungoven TJ, Henderson LA, Meylakh N. Chronic Migraine Pathophysiology and Treatment: A Review of Current Perspectives. Front Pain Res (Lausanne). 2021 Aug 25;2:705276. doi: 10.3389/fpain.2021.705276. PMID: 35295486; PMCID: PMC8915760.
  18. May A, Burstein R. Hypothalamic regulation of headache and migraine. Cephalalgia. 2019 Nov;39(13):1710-1719. doi: 10.1177/0333102419867280. Epub 2019 Aug 29. PMID: 31466456; PMCID: PMC7164212.
  19. Hadjikhani N, Vincent M. Neuroimaging clues of migraine aura. J Headache Pain. 2019 Apr 3;20(1):32. doi: 10.1186/s10194-019-0983-2. PMID: 30943894; PMCID: PMC6734229.
  20. Goadsby PJ, Holland PR, Martins-Oliveira M, Hoffmann J, Schankin C, Akerman S. Pathophysiology of Migraine: A Disorder of Sensory Processing. Physiol Rev. 2017 Apr;97(2):553-622. doi: 10.1152/physrev.00034.2015. PMID: 28179394; PMCID: PMC5539409.
  21. Noseda R. Cerebro-Cerebellar Networks in Migraine Symptoms and Headache. Front Pain Res (Lausanne). 2022 Jul 13;3:940923. doi: 10.3389/fpain.2022.940923. PMID: 35910262; PMCID: PMC9326053.
  22. Yamanaka G, Suzuki S, Morishita N, Takeshita M, Kanou K, Takamatsu T, Suzuki S, Morichi S, Watanabe Y, Ishida Y, Go S, Oana S, Kashiwagi Y, Kawashima H. Role of Neuroinflammation and Blood-Brain Barrier Permutability on Migraine. Int J Mol Sci. 2021 Aug 19;22(16):8929. doi: 10.3390/ijms22168929. PMID: 34445635; PMCID: PMC8396312.
  23. Ferrari MD, Goadsby PJ, Burstein R, Kurth T, Ayata C, Charles A, Ashina M, van den Maagdenberg AMJM, Dodick DW. Migraine. Nat Rev Dis Primers. 2022 Jan 13;8(1):2. doi: 10.1038/s41572-021-00328-4. PMID: 35027572.
  24. Diener HC, Tassorelli C, Dodick DW, Silberstein SD, Lipton RB, Ashina M, Becker WJ, Ferrari MD, Goadsby PJ, Pozo-Rosich P, Wang SJ, Mandrekar J; International Headache Society Clinical Trials Standing Committee. Guidelines of the International Headache Society for controlled trials of acute treatment of migraine attacks in adults: Fourth edition. Cephalalgia. 2019 May;39(6):687-710. doi: 10.1177/0333102419828967. Epub 2019 Feb 26. PMID: 30806518; PMCID: PMC6501455.
  25. Diener HC, Tassorelli C, Dodick DW, Silberstein SD, Lipton RB, Ashina M, Becker WJ, Ferrari MD, Goadsby PJ, Pozo-Rosich P, Wang SJ, Houle TT, Hoek TCVD, Martinelli D, Terwindt GM; International Headache Society Clinical Trials Committee. Guidelines of the International Headache Society for controlled trials of preventive treatment of migraine attacks in episodic migraine in adults. Cephalalgia. 2020 Sep;40(10):1026-1044. doi: 10.1177/0333102420941839. Epub 2020 Jul 28. Erratum in: Cephalalgia. 2020 Aug 18;:333102420952270. PMID: 32722936.
  26. Mehnert J, May A. Functional and structural alterations in the migraine cerebellum. J Cereb Blood Flow Metab. 2019 Apr;39(4):730-739. doi: 10.1177/0271678X17722109. Epub 2017 Jul 24. PMID: 28737061; PMCID: PMC6446424.
  27. Peng KP, May A. Migraine understood as a sensory threshold disease. Pain. 2019 Jul;160(7):1494-1501. doi: 10.1097/j.pain.0000000000001531. PMID: 31219950.
  28. Aurora SK, Brin MF. Chronic Migraine: An Update on Physiology, Imaging, and the Mechanism of Action of Two Available Pharmacologic Therapies. Headache. 2017 Jan;57(1):109-125. doi: 10.1111/head.12999. Epub 2016 Dec 2. PMID: 27910097; PMCID: PMC6681148.
  29. Schulte LH, May A. Of generators, networks and migraine attacks. Curr Opin Neurol. 2017 Jun;30(3):241-245. doi: 10.1097/WCO.0000000000000441. PMID: 28240611.
  30. Gupta VK. Once-weekly nocturnal ocular choroidal vascular decongestion by topical long-acting timolol ophthalmic solution applied to the headache-ipsilateral eye to prevent weekend-migraine attacks: Smartphone-app assisted case report of 2 patients for 3-years and a brief mechanistic review. J Neuroscience and Neurological Surgery. 2021; 8(6) [dOI:10.31579/2578-8868/179]
  31. Gupta VK. Self-ocular compression maneuver immediately relieves migraine headache attacks: A case report of managing 100 attacks over 9 years and a mechanistic review. Acta Scientific Neurology. 2021; 4.8: 72-77. [https://www.actascientific.com/ASNE/pdf/ASNE-04-0407.pdf]
  32. Gupta VK. Reader response: Long-term safety, tolerability, and efficacy of fremanezumab in migraine: A randomized study. Neurology 2020. Submitted September 12.
  33. Gupta VK. Reader response: Facial presentations of migraine, TACs, and other paroxysmal facial pain syndromes. Neurology 2019. Published on September 15.
  34. Gupta VK. Reader response: Gray matter volume modifications in migraine: A cross-sectional and longitudinal study. Neurology. 2019 Mar 19;92(12):587. doi: 10.1212/WNL.0000000000007131. PMID: 30886078.
  35. Gupta VK. Cortical-spreading depression: at the razor's edge of scientific logic. J Headache Pain. 2011 Feb;12(1):45-6. doi: 10.1007/s10194-010-0287-z. Epub 2011 Jan 11. PMID: 21222137; PMCID: PMC3055985.
  36. Gupta V. Constipation-related migraine is linked to the effect of the Valsalva maneuver on the eye: A case report and a mechanistic review. WebmedCentral Neurology. 2010;1(12): WMC001433. [doi: 10.9754/journal.wmc.2010.001433].
  37. Hougaard A, Amin FM, Christensen CE, Younis S, Wolfram F, Cramer SP, Larsson HBW, Ashina M. Increased brainstem perfusion, but no blood-brain barrier disruption, during attacks of migraine with aura. Brain. 2017 Jun 1;140(6):1633-1642. doi: 10.1093/brain/awx089. PMID: 28430860.
  38. Gupta VK. Migrainous scintillating scotoma and headache is ocular in origin: A new hypothesis. Med Hypotheses. 2006;66(3):454-60. doi: 10.1016/j.mehy.2005.11.010. Epub 2005 Dec 13. PMID: 16356654.
  39. Borgdorff P. Arguments against the role of cortical spreading depression in migraine. Neurol Res. 2018 Mar;40(3):173-181. doi: 10.1080/01616412.2018.1428406. Epub 2018 Jan 19. PMID: 29350588.
  40. Lemale CL, Lückl J, Horst V, Reiffurth C, Major S, Hecht N, Woitzik J, Dreier JP. Migraine Aura, Transient Ischemic Attacks, Stroke, and Dying of the Brain Share the Same Key Pathophysiological Process in Neurons Driven by Gibbs-Donnan Forces, Namely Spreading Depolarization. Front Cell Neurosci. 2022 Feb 10;16:837650. doi: 10.3389/fncel.2022.837650. Erratum in: Front Cell Neurosci. 2022 Apr 26;16:917669. PMID: 35237133; PMCID: PMC8884062.
  41. Major S, Huo S, Lemale CL, Siebert E, Milakara D, Woitzik J, Gertz K, Dreier JP. Direct electrophysiological evidence that spreading depolarization-induced spreading depression is the pathophysiological correlate of the migraine aura and a review of the spreading depolarization continuum of acute neuronal mass injury. Geroscience. 2020 Feb;42(1):57-80. doi: 10.1007/s11357-019-00142-7. Epub 2019 Dec 9. PMID: 31820363; PMCID: PMC7031471.
  42. Urbach A, Baum E, Braun F, Witte OW. Cortical spreading depolarization increases adult neurogenesis, and alters behavior and hippocampus-dependent memory in mice. J Cereb Blood Flow Metab. 2017 May;37(5):1776-1790. doi: 10.1177/0271678X16643736. Epub 2016 Jan 1. PMID: 27189903; PMCID: PMC5435280.
  43. Spong KE, Andrew RD, Robertson RM. Mechanisms of spreading depolarization in vertebrate and insect central nervous systems. J Neurophysiol. 2016 Sep 1;116(3):1117-27. doi: 10.1152/jn.00352.2016. Epub 2016 Jun 22. PMID: 27334953; PMCID: PMC5013167.
  44. Rodgers CI, Armstrong GA, Robertson RM. Coma in response to environmental stress in the locust: a model for cortical spreading depression. J Insect Physiol. 2010 Aug;56(8):980-90. doi: 10.1016/j.jinsphys.2010.03.030. Epub 2010 Apr 7. PMID: 20361971.
  45. Rodgers CI, Armstrong GA, Shoemaker KL, LaBrie JD, Moyes CD, Robertson RM. Stress preconditioning of spreading depression in the locust CNS. PLoS One. 2007 Dec 26;2(12):e1366. doi: 10.1371/journal.pone.0001366. PMID: 18159249; PMCID: PMC2137934.
  46. Tamura Y, Eguchi A, Jin G, Sami MM, Kataoka Y. Cortical spreading depression shifts cell fate determination of progenitor cells in the adult cortex. J Cereb Blood Flow Metab. 2012 Oct;32(10):1879-87. doi: 10.1038/jcbfm.2012.98. Epub 2012 Jul 11. PMID: 22781335; PMCID: PMC3463886.
  47. Xue JH, Yanamoto H, Nakajo Y, Tohnai N, Nakano Y, Hori T, Iihara K, Miyamoto S. Induced spreading depression evokes cell division of astrocytes in the subpial zone, generating neural precursor-like cells and new immature neurons in the adult cerebral cortex. Stroke. 2009 Nov;40(11):e606-13. doi: 10.1161/STROKEAHA.109.560334. Epub 2009 Sep 24. Erratum in: Stroke. 2010 Jul;41(7):e511. PMID: 19797181.
  48. Yanamoto H, Miyamoto S, Tohnai N, Nagata I, Xue JH, Nakano Y, Nakajo Y, Kikuchi H. Induced spreading depression activates persistent neurogenesis in the subventricular zone, generating cells with markers for divided and early committed neurons in the caudate putamen and cortex. Stroke. 2005 Jul;36(7):1544-50. doi: 10.1161/01.STR.0000169903.09253.c7. Epub 2005 Jun 2. PMID: 15933264.
  49. Hao Y, Xin M, Feng L, Wang X, Wang X, Ma D, Feng J. Review Cerebral Ischemic Tolerance and Preconditioning: Methods, Mechanisms, Clinical Applications, and Challenges. Front Neurol. 2020 Sep 18;11:812. doi: 10.3389/fneur.2020.00812. PMID: 33071923; PMCID: PMC7530891.
  50. Drongitis D, Rainone S, Piscopo M, Viggiano E, Viggiano A, De Luca B, Fucci L, Donizetti A. Epigenetics and cortical spreading depression: changes of DNA methylation level at retrotransposon sequences. Mol Biol Rep. 2016 Aug;43(8):755-60. doi: 10.1007/s11033-016-4000-4. Epub 2016 May 12. PMID: 27169424.
  51. Shen PP, Hou S, Ma D, Zhao MM, Zhu MQ, Zhang JD, Feng LS, Cui L, Feng JC. Cortical spreading depression-induced preconditioning in the brain. Neural Regen Res. 2016 Nov;11(11):1857-1864. doi: 10.4103/1673-5374.194759. PMID: 28123433; PMCID: PMC5204245.
  52. Yanamoto H, Xue JH, Miyamoto S, Nagata I, Nakano Y, Murao K, Kikuchi H. Spreading depression induces long-lasting brain protection against infarcted lesion development via BDNF gene-dependent mechanism. Brain Res. 2004 Sep 3;1019(1-2):178-88. doi: 10.1016/j.brainres.2004.05.105. PMID: 15306252.
  53. Yanamoto H, Mizuta I, Nagata I, Xue J, Zhang Z, Kikuchi H. Infarct tolerance accompanied enhanced BDNF-like immunoreactivity in neuronal nuclei. Brain Res. 2000 Sep 22;877(2):331-44. doi: 10.1016/s0006-8993(00)02718-9. PMID: 10986348.
  54. Rangel YM, Karikó K, Harris VA, Duvall ME, Welsh FA. Dose-dependent induction of mRNAs encoding brain-derived neurotrophic factor and heat-shock protein-72 after cortical spreading depression in the rat. Brain Res Mol Brain Res. 2001 Mar 31;88(1-2):103-12. doi: 10.1016/s0169-328x(01)00037-7. PMID: 11295236.
  55. Kobayashi S, Harris VA, Welsh FA. Spreading depression induces tolerance of cortical neurons to ischemia in rat brain. J Cereb Blood Flow Metab. 1995 Sep;15(5):721-7. doi: 10.1038/jcbfm.1995.92. PMID: 7673367.
  56. Zhou N, Rungta RL, Malik A, Han H, Wu DC, MacVicar BA. Regenerative glutamate release by presynaptic NMDA receptors contributes to spreading depression. J Cereb Blood Flow Metab. 2013 Oct;33(10):1582-94. doi: 10.1038/jcbfm.2013.113. Epub 2013 Jul 3. PMID: 23820646; PMCID: PMC3790928.
  57. Park CG, Chu MK. Interictal plasma glutamate levels are elevated in individuals with episodic and chronic migraine. Sci Rep. 2022 Apr 28;12(1):6921. doi: 10.1038/s41598-022-10883-9. PMID: 35484312; PMCID: PMC9050726.
  58. Perez-Rando M, Carceller H, Castillo-Gomez E, Bueno-Fernandez C, García-Mompó C, Gilabert-Juan J, Guirado R, Pesarico AP, Nacher J. Impact of stress on inhibitory neuronal circuits, our tribute to Bruce McEwen. Neurobiol Stress. 2022 May 13;19:100460. doi: 10.1016/j.ynstr.2022.100460. PMID: 35734023; PMCID: PMC9207718.
  59. Pietrancosta N, Djibo M, Daumas S, El Mestikawy S, Erickson JD. Molecular, Structural, Functional, and Pharmacological Sites for Vesicular Glutamate Transporter Regulation. Mol Neurobiol. 2020 Jul;57(7):3118-3142. doi: 10.1007/s12035-020-01912-7. Epub 2020 May 30. PMID: 32474835; PMCID: PMC7261050.
  60. Nedergaard M, Hansen AJ. Spreading depression is not associated with neuronal injury in the normal brain. Brain Res. 1988 May 24;449(1-2):395-8. doi: 10.1016/0006-8993(88)91062-1. PMID: 3395856.
  61. Carlson AP, Shuttleworth CW, Mead B, Burlbaw B, Krasberg M, Yonas H. Cortical spreading depression occurs during elective neurosurgical procedures. J Neurosurg. 2017 Jan;126(1):266-273. doi: 10.3171/2015.11.JNS151871. Epub 2016 Mar 11. PMID: 26967779.
  62. Koroleva VI, Bures J. Rats do not experience cortical or hippocampal spreading depression as aversive. Neurosci Lett. 1993 Jan 12;149(2):153-6. doi: 10.1016/0304-3940(93)90759-e. PMID: 8474690.
  63. Peréz-Saad H, Bures J. Cortical spreading depression blocks naloxone-induced escape behaviour in morphine pretreated mice. Pharmacol Biochem Behav. 1983 Jan;18(1):145-7. doi: 10.1016/0091-3057(83)90265-4. PMID: 6828533.
  64. Huston JP, Bures J. Effects of cortical spreading depression on behaviors elicited by hypothalamic stimulation in rats. Physiol Behav. 1973 Apr;10(4):775-80. doi: 10.1016/0031-9384(73)90162-5. PMID: 4575411.
  65. Huston JP, Bures J. Drinking and eating elicited by cortical spreading depression. Science. 1970 Aug 14;169(3946):702-4. doi: 10.1126/science.169.3946.702. PMID: 5464304.
  66. Carew TJ, Crow TJ, Petrinovich LF. Lack of coincidence between neural and behavioral manifestations of cortical spreading depression. Science. 1970 Sep 25;169(3952):1339-42. doi: 10.1126/science.169.3952.1339. PMID: 5454148.
  67. Tamim I, Chung DY, de Morais AL, Loonen ICM, Qin T, Misra A, Schlunk F, Endres M, Schiff SJ, Ayata C. Spreading depression as an innate antiseizure mechanism. Nat Commun 2021;12(1):2206. [PMID: 33850125] [doi: 10.1038/s41467-021-22464-x]
  68. Melo-Carrillo A, Schain AJ, Stratton J, Strassman AM, Burstein R. Fremanezumab and its isotype slow propagation rate and shorten cortical recovery period but do not prevent occurrence of cortical spreading depression in rats with compromised blood-brain barrier. Pain. 2020 May;161(5):1037-1043. doi: 10.1097/j.pain.0000000000001791. PMID: 31895266; PMCID: PMC7166155.
  69. Schain AJ, Melo-Carrillo A, Stratton J, Strassman AM, Burstein R. CSD-Induced Arterial Dilatation and Plasma Protein Extravasation Are Unaffected by Fremanezumab: Implications for CGRP's Role in Migraine with Aura. J Neurosci. 2019 Jul 24;39(30):6001-6011. doi: 10.1523/JNEUROSCI.0232-19.2019. Epub 2019 May 24. PMID: 31127003; PMCID: PMC6650995.
  70. Huang JY, Su CC, Wang TH, Tsai IJ. Migraine and increased risk of developing open angle glaucoma: a population-based cohort study. BMC Ophthalmol. 2019 Feb 13;19(1):50. doi: 10.1186/s12886-019-1062-9. PMID: 30760249; PMCID: PMC6375150.
  71. Xu C, Li J, Li Z, Mao X. Migraine as a risk factor for primary open angle glaucoma: A systematic review and meta-analysis. Medicine (Baltimore). 2018 Jul;97(28):e11377. doi: 10.1097/MD.0000000000011377. PMID: 29995778; PMCID: PMC6076184.
  72. Pradalier A, Hamard P, Sellem E, Bringer L. Migraine and glaucoma: an epidemiologic survey of French ophthalmologists. Cephalalgia. 1998 Mar;18(2):74-6. doi: 10.1046/j.1468-2982.1998.1802074.x. PMID: 9533601.
  73. Phelps CD, Corbett JJ. Migraine and low-tension glaucoma. A case-control study. Invest Ophthalmol Vis Sci. 1985 Aug;26(8):1105-8. PMID: 4019101.
  74. Wooliscroft J, Akram R, Zuberi H, Tong B, Gu J, Hurd A, Kooner K. Predictors of Early Onset Glaucoma. Clin Ophthalmol. 2022 Jun 10;16:1925-1932. doi: 10.2147/OPTH.S360719. PMID: 35711969; PMCID: PMC9196659.
  75. Chen HY, Lin CL, Kao CH. Does Migraine Increase the Risk of Glaucoma?: A Population-Based Cohort Study. Medicine (Baltimore). 2016 May;95(19):e3670. doi: 10.1097/MD.0000000000003670. PMID: 27175700; PMCID: PMC4902542.
  76. McKendrick AM, Nguyen BN. The eye in migraine: a review of retinal imaging findings in migraine. Clin Exp Optom. 2022 Mar;105(2):186-193. doi: 10.1080/08164622.2021.1971045. Epub 2021 Sep 19. PMID: 34538219.
  77. Hupp SL, Kline LB, Corbett JJ. Visual disturbances of migraine. Surv Ophthalmol. 1989 Jan-Feb;33(4):221-36. doi: 10.1016/0039-6257(82)90149-7. PMID: 2652358.
  78. Nguyen BN, Lek JJ, Vingrys AJ, McKendrick AM. Clinical impact of migraine for the management of glaucoma patients. Prog Retin Eye Res. 2016 Mar;51:107-24. doi: 10.1016/j.preteyeres.2015.07.006. Epub 2015 Jul 29. PMID: 26232725.
  79. Lisicki M, Ruiz-Romagnoli E, Piedrabuena R, Giobellina R, Schoenen J, Magis D. Migraine triggers and habituation of visual evoked potentials. Cephalalgia. 2018 Apr;38(5):988-992. doi: 10.1177/0333102417720217. Epub 2017 Jul 10. PMID: 28691517.
  80. Magis D, Lisicki M, Coppola G. Highlights in migraine electrophysiology: are controversies just reflecting disease heterogeneity? Curr Opin Neurol. 2016 Jun;29(3):320-30. doi: 10.1097/WCO.0000000000000335. PMID: 27120104.
  81. Gupta VK. Migraine, cortical excitability and evoked potentials: a clinico-pharmacological perspective. Brain. 2005 Sep;128(Pt 9):E36; author reply E37. doi: 10.1093/brain/awh606. PMID: 16129875.
  82. Omland PM, Nilsen KB, Uglem M, Gravdahl G, Linde M, Hagen K, Sand T. Visual evoked potentials in interictal migraine: no confirmation of abnormal habituation. Headache. 2013 Jul-Aug;53(7):1071-86. doi: 10.1111/head.12006. Epub 2013 Jan 8. PMID: 23298223.
  83. Gupta VK. Visual function impairment in migraine: cerebral versus retinal deficit. Cephalalgia. 1993 Dec;13(6):431-3. doi: 10.1046/j.1468-2982.1993.1306431.x. PMID: 8313461.
  84. Gupta VK. A hypothesis for the migraine headache syndrome. Spirit of Enterprise. The 1990 Rolex Awards. Buri International, Bern, Switzerland, 1990; 155.
  85. Huo YJ, Thomas R, Li L, Cao K, Wang HZ, Wang NL. Comparison of Peripapillary Retinal Nerve Fiber Layer Thickness, Functional Subzones, and Macular Ganglion Cell-Inner Plexiform Layer in Differentiating Patients With Mild, Moderate, and Severe Open-angle Glaucoma. J Glaucoma. 2020 Sep;29(9):761-766. doi: 10.1097/IJG.0000000000001598. PMID: 32657819.
  86. Edlinger FSM, Schrems-Hoesl LM, Mardin CY, Laemmer R, Kruse FE, Schrems WA. Structural changes of macular inner retinal layers in early normal-tension and high-tension glaucoma by spectral-domain optical coherence tomography. Graefes Arch Clin Exp Ophthalmol. 2018 Jul;256(7):1245-1256. doi: 10.1007/s00417-018-3944-6. Epub 2018 Mar 9. PMID: 29523993.
  87. Lin X, Yi Z, Zhang X, Liu Q, Zhang H, Cai R, Chen C, Zhang H, Zhao P, Pan P. Retinal nerve fiber layer changes in migraine: a systematic review and meta-analysis. Neurol Sci. 2021 Mar;42(3):871-881. doi: 10.1007/s10072-020-04992-4. Epub 2021 Jan 13. PMID: 33439389.
  88. Hamurcu MS, Gultekin BP, Koca S, Ece SD. Evaluation of migraine patients with optical coherence tomography angiography. Int Ophthalmol. 2021 Dec;41(12):3929-3933. doi: 10.1007/s10792-021-01962-3. Epub 2021 Jul 22. PMID: 34291402.
  89. Altunisik E, Oren B. Retinal Neurovascular Structural Changes in Optical Coherence Tomography and the Relationship between These Changes and White Matter Hyperintensities in Patients with Migraine. Eur Neurol. 2021;84(6):460-471. doi: 10.1159/000518380. Epub 2021 Aug 30. PMID: 34515117.
  90. Gouravani M, Salehi MA, Mohammadi S, Arevalo JF. Choroidal thickness in eyes of migraine patients measured using spectral domain-optical coherence tomography: A meta-analysis. Surv Ophthalmol. 2023 Jan-Feb;68(1):67-77. doi: 10.1016/j.survophthal.2022.01.007. Epub 2022 Jan 31. PMID: 35093402.
  91. Karaca EE, Koçer EB, Özdek Ş, Akçam HT, Ercan MB. Choroidal thickness measurements in migraine patients during attack-free period. Neurol Sci. 2016 Jan;37(1):81-88. doi: 10.1007/s10072-015-2364-1. Epub 2015 Aug 15. PMID: 26276221.
  92. Colak HN, Kantarcı FA, Tatar MG, Eryilmaz M, Uslu H, Goker H, Yildirim A, Gurler B. Retinal nerve fiber layer, ganglion cell complex, and choroidal thicknesses in migraine. Arq Bras Oftalmol. 2016 Apr;79(2):78-81. doi: 10.5935/0004-2749.20160024. PMID: 27224067.
  93. Dervisogullari MS, Totan Y, Gençler OS. Choroid thickness and ocular pulse amplitude in migraine during attack. Eye (Lond). 2015 Mar;29(3):371-5. doi: 10.1038/eye.2014.299. Epub 2014 Dec 12. Erratum in: Eye (Lond). 2015 Mar;29(3):452. PMID: 25502868; PMCID: PMC4366466.
  94. Ekinci M, Ceylan E, Cağatay HH, Keleş S, Hüseyinoğlu N, Tanyildiz B, Cakici O, Kartal B. Retinal nerve fibre layer, ganglion cell layer and choroid thinning in migraine with aura. BMC Ophthalmol. 2014 May 31;14:75. doi: 10.1186/1471-2415-14-75. PMID: 24885597; PMCID: PMC4229806.
  95. Yener AÜ, Korucu O. Visual Field Losses in Patients with Migraine without Aura and Tension-Type Headache. Neuroophthalmology. 2017 Jan 11;41(2):59-67. doi: 10.1080/01658107.2016.1251466. PMID: 28348627; PMCID: PMC5354103.
  96. McKendrick AM, Badcock DR. Decreased visual field sensitivity measured 1 day, then 1 week, after migraine. Invest Ophthalmol Vis Sci. 2004 Apr;45(4):1061-70. doi: 10.1167/iovs.03-0936. PMID: 15037569.
  97. Lewis RA, Vijayan N, Watson C, Keltner J, Johnson CA. Visual field loss in migraine. Ophthalmology. 1989; 96:321-326. [PMID: 2710523] [doi: 10.1016/s0161-6420(89)33069-7]
  98. Battista J, Badcock DR, McKendrick AM. Migraine increases centre-surround suppression for drifting visual stimuli. PLoS One. 2011 Apr 11;6(4):e18211. doi: 10.1371/journal.pone.0018211. PMID: 21494594; PMCID: PMC3073931.
  99. Gupta VK. Reader response: Long-term efficacy and safety of erenumab: Results from 64 weeks of the LIBERTY study. Neurology 2021. Submitted on May 05, 2021.
  100. Gupta VK. Reader response: Effect of fremanezumab on quality of life and productivity in patients with chronic migraine. Neurology 2020. Submitted August 10.
  101. Noseda R, Schain AJ, Melo-Carrillo A, Tien J, Stratton J, Mai F, Strassman AM, Burstein R. Fluorescently-labeled fremanezumab is distributed to sensory and autonomic ganglia and the dura but not to the brain of rats with uncompromised blood brain barrier. Cephalalgia. 2020 Mar;40(3):229-240. doi: 10.1177/0333102419896760. Epub 2019 Dec 19. PMID: 31856583; PMCID: PMC7233263.
  102. Johnson KW, Morin SM, Wroblewski VJ, Johnson MP. Peripheral and central nervous system distribution of the CGRP neutralizing antibody [125I] galcanezumab in male rats. Cephalalgia. 2019 Sep;39(10):1241-1248. doi: 10.1177/0333102419844711. Epub 2019 Apr 19. PMID: 31003588.
  103. Basedau H, Sturm LM, Mehnert J, Peng KP, Schellong M, May A. Migraine monoclonal antibodies against CGRP change brain activity depending on ligand or receptor target - an fMRI study. Elife. 2022 May 23;11:e77146. doi: 10.7554/eLife.77146. PMID: 35604755; PMCID: PMC9126581.
  104. Gupta VK. Pharmacotherapeutics of migraine and the blood-brain barrier: serendipity, empiricism, hope, and hype. MedGenMed. 2006 Jun 28;8(2):89. PMID: 16926828; PMCID: PMC1785228.
  105. Gupta VK. Systemic hypertension, headache, and ocular hemodynamics: a new hypothesis. MedGenMed. 2006 Sep 12;8(3):63. PMID: 17406187; PMCID: PMC1781314.
  106. Kurian A, Reghunadhan I, Thilak P, Soman I, Nair U. Short-term Efficacy and Safety of Topical β-Blockers (Timolol Maleate Ophthalmic Solution, 0.5%) in Acute Migraine: A Randomized Crossover Trial. JAMA Ophthalmol. 2020 Nov 1;138(11):1160-1166. doi: 10.1001/jamaophthalmol.2020.3676. PMID: 33001159; PMCID: PMC7530820.
  107. Aggarwal D, Heim AJ, Bittel B, Ford D, Dubinsky R, Gronseth G, Hairston V, Landazuri P, Sachen F, Herbelin L, Barohn RJ. A Randomized, Double-Blinded, Placebo-Controlled, Cross Over Study Evaluating the Efficacy and Safety of Timolol Ophthalmic Solution as an Acute Treatment of Migraine. Kans J Med. 2020 Feb 26;13(Suppl 2):2-5. PMID: 32256967; PMCID: PMC7106987.
  108. Gratton S, Cossack M. Answering the Call: A Prospective Look at the Role of Timolol Eye Drops in the Treatment of Acute Migraine Attacks. Mo Med. 2018 Nov-Dec;115(6):520-521. PMID: 30643343; PMCID: PMC6312165.
  109. Cossack M, Nabrinsky E, Turner H, Abraham A, Gratton S. Timolol Eyedrops in the Treatment of Acute Migraine Attacks: A Randomized Crossover Study. JAMA Neurol. 2018 Aug 1;75(8):1024-1025. doi: 10.1001/jamaneurol.2018.0970. Erratum in: JAMA Neurol. 2018 Aug 1;75(8):1028. Erratum in: JAMA Neurol. 2018 Oct 1;75(10):1287. PMID: 29799915; PMCID: PMC6142935.
  110. Migliazzo CV, Hagan JC 3rd. Beta blocker eye drops for treatment of acute migraine. Mo Med. 2014 Jul-Aug;111(4):283-8. PMID: 25211851; PMCID: PMC6179466.
  111. Banerjee M, Findley L. Propranolol in the treatment of acute migraine attacks. Cephalalgia. 1991 Sep;11(4):193-6. doi: 10.1046/j.1468-2982.1991.1104193.x. PMID: 1742775.
  112. Fuller GN, Guiloff RJ. Propranolol in acute migraine: a controlled study. Cephalalgia. 1990 Oct;10(5):229-33. doi: 10.1046/j.1468-2982.1990.1005229.x. PMID: 2272092.
  113. Featherstone HJ. Low-dose propranolol therapy for aborting migraine. West J Med. 1983 Mar;138(3):416-7. PMID: 6858129; PMCID: PMC1021497.
  114. Tokola R, Hokkanen E. Propranolol for acute migraine. Br Med J. 1978 Oct 14;2(6144):1089. doi: 10.1136/bmj.2.6144.1089-a. PMID: 709242; PMCID: PMC1608141.
  115. Marteau TM, Bekker H. The development of a six-item short-form of the state scale of the Spielberger State-Trait Anxiety Inventory (STAI). Br J Clin Psychol. 1992 Sep;31(3):301-6. doi: 10.1111/j.2044-8260.1992.tb00997.x. Erratum in: Br J Clin Psychol. 2020 Jun;59(2):276. PMID: 1393159.
  116. Kiel JW. The Ocular Circulation. San Rafael (CA): Morgan & Claypool Life Sciences; 2010. PMID: 21452447.
  117. Gupta VK. Botulinum toxin type A therapy for chronic tension-type headache: fact versus fiction. Pain. 2005 Jul;116(1-2):166-7; author reply 167. doi: 10.1016/j.pain.2005.03.033. PMID: 15927392.
  118. Gupta VK. Closure of atrial septal defect and migraine. Headache. 2004 Mar;44(3):291-2. doi: 10.1111/j.1526-4610.2004.t01-2-04063.x. PMID: 15012673.
  119. Zhu Y, Li S, Li J, Falcone N, Cui Q, Shah S, Hartel MC, Yu N, Young P, de Barros NR, Wu Z, Haghniaz R, Ermis M, Wang C, Kang H, Lee J, Karamikamkar S, Ahadian S, Jucaud V, Dokmeci MR, Kim HJ, Khademhosseini A. Lab-on-a-Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics. Adv Mater. 2022 Jun;34(24):e2108389. doi: 10.1002/adma.202108389. Epub 2022 Apr 11. PMID: 35130584; PMCID: PMC9233032.
  120. Zhao Y, Hu G, Yan Y, Wang Z, Liu X, Shi H. Biomechanical analysis of ocular diseases and its in vitro study methods. Biomed Eng Online. 2022 Jul 23;21(1):49. doi: 10.1186/s12938-022-01019-1. PMID: 35870978; PMCID: PMC9308301.
  121. Safa BN, Wong CA, Ha J, Ethier CR. Glaucoma and biomechanics. Curr Opin Ophthalmol. 2022 Mar 1;33(2):80-90. doi: 10.1097/ICU.0000000000000829. PMID: 34954731; PMCID: PMC8828701.
  122. Dennyson Savariraj A, Salih A, Alam F, Elsherif M, AlQattan B, Khan AA, Yetisen AK, Butt H. Ophthalmic Sensors and Drug Delivery. ACS Sens. 2021 Jun 25;6(6):2046-2076. doi: 10.1021/acssensors.1c00370. Epub 2021 May 27. PMID: 34043907; PMCID: PMC8294612.
  123. Gupta VK. Orbitofrontal cortex hypometabolism, medication overuse headache, substance abuse and migraine: key pathophysiological issues. Brain. 2006 Jul;129(Pt 7):E52; author reply E53. doi: 10.1093/brain/awl119. PMID: 16803837.
  124. Silva GC, Góes CP, Vincent MB. Aura-like features and photophobia in sightless migraine patients. Arq Neuropsiquiatr. 2014 Dec;72(12):949-53. doi: 10.1590/0004-282X20140200. PMID: 25517643.
  125. Rasmussen ML. The eye amputated - consequences of eye amputation with emphasis on clinical aspects, phantom eye syndrome and quality of life. Acta Ophthalmol. 2010 Dec;88 Thesis 2:1-26. doi: 10.1111/j.1755-3768.2010.02039.x. PMID: 21108770.
  126. Noseda R, Kainz V, Jakubowski M, Gooley JJ, Saper CB, Digre K, Burstein R. A neural mechanism for exacerbation of headache by light. Nat Neurosci. 2010 Feb;13(2):239-45. doi: 10.1038/nn.2475. Epub 2010 Jan 10. PMID: 20062053; PMCID: PMC2818758.
  127. Sörös P, Vo O, Husstedt IW, Evers S, Gerding H. Phantom eye syndrome: Its prevalence, phenomenology, and putative mechanisms. Neurology. 2003 May 13;60(9):1542-3. doi: 10.1212/01.wnl.0000059547.68899.f5. PMID: 12743251.
  128. Custer PL, Reistad CE. Enucleation of blind, painful eyes. Ophthalmic Plast Reconstr Surg. 2000 Sep;16(5):326-9. doi: 10.1097/00002341-200009000-00004. PMID: 11021380.
  129. Nicolodi M, Frezzotti R, Diadori A, Nuti A, Sicuteri F. Phantom eye: features and prevalence. The predisposing role of headache. Cephalalgia. 1997 Jun;17(4):501-4. doi: 10.1046/j.1468-2982.1997.1704501.x. PMID: 9209770.
  130. Peatfield RC, Rose FC. Migrainous visual symptoms in a woman without eyes. Arch Neurol. 1981 Jul;38(7):466. doi: 10.1001/archneur.1981.00510070100024. PMID: 7247775.
  131. Koban Y, Ozlece HK, Bilgin G, Koc M, Cagatay HH, Durgunlu EI, Burcu A. Intraocular pressure and ocular biometric parameters changes in migraine. BMC Ophthalmol. 2016 May 31;16:70. doi: 10.1186/s12886-016-0258-5. PMID: 27245325; PMCID: PMC4886420.
  132. Gupta VK. A clinical review of the adaptive role of vasopressin in migraine. Cephalalgia. 1997 Aug;17(5):561-9. doi: 10.1046/j.1468-2982.1997.1705561.x. PMID: 9251870.
  133. Dodick DW. A Phase-by-Phase Review of Migraine Pathophysiology. Headache. 2018 May;58 Suppl 1:4-16. doi: 10.1111/head.13300. PMID: 29697154.
  134. Knapp L, Szita B, Kocsis K, Vécsei L, Toldi J. Nitroglycerin enhances the propagation of cortical spreading depression: comparative studies with sumatriptan and novel kynurenic acid analogues. Drug Des Devel Ther. 2016 Dec 20;11:27-34. doi: 10.2147/DDDT.S117166. PMID: 28053504; PMCID: PMC5191838.
  135. Butt JH, S Eddelien H, Kruuse C. The headache and aura-inducing effects of sildenafil in patients with migraine with aura. Cephalalgia. 2022 Sep;42(10):984-992. doi: 10.1177/03331024221088998. Epub 2022 Mar 25. PMID: 35332812.
  136. Khan S, Deen M, Hougaard A, Amin FM, Ashina M. Reproducibility of migraine-like attacks induced by phosphodiesterase-3-inhibitor cilostazol. Cephalalgia. 2018 Apr;38(5):892-903. doi: 10.1177/0333102417719753. Epub 2017 Jul 5. PMID: 28677994.
  137. Kruuse C, Thomsen LL, Birk S, Olesen J. Migraine can be induced by sildenafil without changes in middle cerebral artery diameter. Brain. 2003 Jan;126(Pt 1):241-7. doi: 10.1093/brain/awg009. PMID: 12477710.
  138. Kruuse C, Thomsen LL, Jacobsen TB, Olesen J. The phosphodiesterase 5 inhibitor sildenafil has no effect on cerebral blood flow or blood velocity, but nevertheless induces headache in healthy subjects. J Cereb Blood Flow Metab. 2002 Sep;22(9):1124-31. doi: 10.1097/00004647-200209000-00010. PMID: 12218418.
  139. Wang M, Urenjak J, Fedele E, Obrenovitch TP. Effects of phosphodiesterase inhibition on cortical spreading depression and associated changes in extracellular cyclic GMP. Biochem Pharmacol. 2004 Apr 15;67(8):1619-27. doi: 10.1016/j.bcp.2003.12.029. PMID: 15041479.
  140. Gerometta R, Alvarez LJ, Candia OA. Effect of sildenafil citrate on intraocular pressure and blood pressure in human volunteers. Exp Eye Res. 2011 Jul;93(1):103-7. doi: 10.1016/j.exer.2011.05.010. Epub 2011 May 30. PMID: 21651908; PMCID: PMC3138881.
  141. Khan S, Amin FM, Christensen CE, Ghanizada H, Younis S, Olinger ACR, de Koning PJH, Larsson HBW, Ashina M. Meningeal contribution to migraine pain: a magnetic resonance angiography study. Brain. 2019 Jan 1;142(1):93-102. doi: 10.1093/brain/awy300. PMID: 30590467.
  142. VanDenBrink AM, Duncker DJ, Saxena PR. Migraine headache is not associated with cerebral or meningeal vasodilatation--a 3T magnetic resonance angiography study. Brain. 2009 Jun;132(Pt 6):e112; author reply e113. doi: 10.1093/brain/awn259. Epub 2008 Oct 14. PMID: 18854326.
  143. Schoonman GG, van der Grond J, Kortmann C, van der Geest RJ, Terwindt GM, Ferrari MD. Migraine headache is not associated with cerebral or meningeal vasodilatation--a 3T magnetic resonance angiography study. Brain. 2008 Aug;131(Pt 8):2192-200. doi: 10.1093/brain/awn094. Epub 2008 May 23. PMID: 18502781.
  144. North K, Slayden A, Mysiewicz S, Bukiya A, Dopico A. Celastrol Dilates and Counteracts Ethanol-Induced Constriction of Cerebral Arteries. J Pharmacol Exp Ther. 2020 Nov;375(2):247-257. doi: 10.1124/jpet.120.000152. Epub 2020 Aug 29. PMID: 32862144; PMCID: PMC7589950.
  145. Bukiya A, Dopico AM, Leffler CW, Fedinec A. Dietary cholesterol protects against alcohol-induced cerebral artery constriction. Alcohol Clin Exp Res. 2014 May;38(5):1216-26. doi: 10.1111/acer.12373. Epub 2014 Mar 3. PMID: 24588122; PMCID: PMC4010119.
  146. de Jong PTVM, Thee EF, Straver B. Ebstein anomaly associated with retinal venular dilatation, migraine, and visual snow syndrome: a case report. BMC Ophthalmol. 2022 Feb 14;22(1):75. doi: 10.1186/s12886-022-02288-z. PMID: 35164715; PMCID: PMC8845237.
  147. Shi M, Luo D, Guo J, Yang D, Li Z, Zhao H. The Function of the Autonomic Nervous System in Asian Patients With Chronic Migraine. Front Neurosci. 2022 Apr 14;16:773321. doi: 10.3389/fnins.2022.773321. PMID: 35495060; PMCID: PMC9047659.
  148. Kristoffersen ES, Børte S, Hagen K, Zwart JA, Winsvold BS. Migraine, obesity and body fat distribution - a population-based study. J Headache Pain. 2020 Aug 6;21(1):97. doi: 10.1186/s10194-020-01163-w. PMID: 32762643; PMCID: PMC7409451.
  149. Reddy A, Halenda K, Cromer P, Chen L, Butler J, Raed A, Bhagatwala J, Sponseller T, Bollinger K, Zhu H, Young L, Layman D, Dong Y. The Association of Intraocular Pressure With Obesity and Cardiometabolic Risk in a Young Farmworker Population. J Glaucoma. 2021 Jan 1;30(1):24-31. doi: 10.1097/IJG.0000000000001673. PMID: 33065612.
  150. Rivera-Mancilla E, Al-Hassany L, Villalón CM, MaassenVanDenBrink A. Metabolic Aspects of Migraine: Association With Obesity and Diabetes Mellitus. Front Neurol. 2021 Jun 9;12:686398. doi: 10.3389/fneur.2021.686398. PMID: 34177788; PMCID: PMC8219973.
  151. Walter SM, Dai Z, Wang K. Obesity, Migraine, and Overlapping Comorbidities in a Rural Pediatric Population. J Neurosci Rural Pract. 2021 Jul;12(3):524-529. doi: 10.1055/s-0041-1727574. Epub 2021 May 10. PMID: 34295107; PMCID: PMC8289561.
  152. Cortez MM, Millsap L, Brennan KC, Campbell CL. Craniofacial Autonomic Dysfunction in Migraine: Implications for Treatment and Prognosis. J Neuroophthalmol. 2020 Mar;40(1):67-73. doi: 10.1097/WNO.0000000000000876. PMID: 31895071.
  153. Miglis MG. Migraine and Autonomic Dysfunction: Which Is the Horse and Which Is the Jockey? Curr Pain Headache Rep. 2018 Feb 23;22(3):19. doi: 10.1007/s11916-018-0671-y. PMID: 29476276.
  154. Gazerani P, Cairns BE. Dysautonomia in the pathogenesis of migraine. Expert Rev Neurother. 2018 Feb;18(2):153-165. doi: 10.1080/14737175.2018.1414601. Epub 2017 Dec 13. PMID: 29212396.
  155. Volman M, Mojadidi MK, Gevorgyan R, Kaing A, Agrawal H, Tobis J. Incidence of patent foramen ovale and migraine headache in adults with congenital heart disease with no known cardiac shunts. Catheter Cardiovasc Interv. 2013 Mar;81(4):643-7. doi: 10.1002/ccd.24635. Epub 2012 Nov 14. PMID: 22927216.
  156. Pileggi C, Papadopoli R, De Sarro C, Nobile CGA, Pavia M. Obesity, Blood Pressure, and Intraocular Pressure: A Cross-Sectional Study in Italian Children. Obes Facts. 2021;14(2):169-177. doi: 10.1159/000514096. Epub 2021 Apr 1. PMID: 33794545; PMCID: PMC8138192.
  157. Ahn MW, Lee JW, Shin JH, Lee JS. Relationship between intraocular pressure and parameters of obesity in ocular hypertension. Int J Ophthalmol. 2020 May 18;13(5):794-800. doi: 10.18240/ijo.2020.05.15. PMID: 32420228; PMCID: PMC7201358.
  158. Vo M, Ainalem A, Qiu C, Peterlin BL, Aurora SK, Williams MA. Body mass index and adult weight gain among reproductive age women with migraine. Headache. 2011 Apr;51(4):559-69. doi: 10.1111/j.1526-4610.2010.01833.x. Epub 2011 Jan 26. PMID: 21269300; PMCID: PMC3187699.
  159. Gidding SS, Nehgme R, Heise C, Muscar C, Linton A, Hassink S. Severe obesity associated with cardiovascular deconditioning, high prevalence of cardiovascular risk factors, diabetes mellitus/hyperinsulinemia, and respiratory compromise. J Pediatr. 2004 Jun;144(6):766-9. doi: 10.1016/j.jpeds.2004.03.043. PMID: 15192624.
  160. Giardini A, Moore P, Brook M, Stratton V, Tacy T. Effect of transcatheter atrial septal defect closure in children on left ventricular diastolic function. Am J Cardiol. 2005 May 15;95(10):1255-7. doi: 10.1016/j.amjcard.2005.01.062. PMID: 15878007.
  161. Gupta VK. Patent foramen ovale closure and migraine: science and sensibility. Expert Rev Neurother. 2010 Sep;10(9):1409-22. doi: 10.1586/ern.10.125. PMID: 20819012.
  162. Gupta VK. Closure of PFO: science, quasi-science, or empiricism. Cardiology. 2009;113(2):108-10. doi: 10.1159/000174289. Epub 2008 Nov 21. PMID: 19023202.
  163. Zhang Y, Wang H, Liu L. Patent Foramen Ovale Closure for Treating Migraine: A Meta-Analysis. J Interv Cardiol. 2022 Feb 2;2022:6456272. doi: 10.1155/2022/6456272. PMID: 35185398; PMCID: PMC8828350.
  164. Mojadidi MK, Kumar P, Mahmoud AN, Elgendy IY, Shapiro H, West B, Charles AC, Mattle HP, Sorensen S, Meier B, Silberstein SD, Tobis JM. Pooled Analysis of PFO Occluder Device Trials in Patients With PFO and Migraine. J Am Coll Cardiol. 2021 Feb 16;77(6):667-676. doi: 10.1016/j.jacc.2020.11.068. PMID: 33573735.
  165. Elbadawi A, Barssoum K, Abuzaid AS, Rezq A, Biniwale N, Alotaki E, Mohamed AH, Vuyyala S, Ogunbayo GO, Saad M. Meta-analysis of randomized trials on percutaneous patent foramen ovale closure for prevention of migraine. Acta Cardiol. 2019 Apr;74(2):124-129. doi: 10.1080/00015385.2018.1475027. Epub 2018 Jun 18. PMID: 29914296.
  166. Tobis JM, Charles A, Silberstein SD, Sorensen S, Maini B, Horwitz PA, Gurley JC. Percutaneous Closure of Patent Foramen Ovale in Patients With Migraine: The PREMIUM Trial. J Am Coll Cardiol. 2017 Dec 5;70(22):2766-2774. doi: 10.1016/j.jacc.2017.09.1105. PMID: 29191325.
  167. Mattle HP, Evers S, Hildick-Smith D, Becker WJ, Baumgartner H, Chataway J, Gawel M, Göbel H, Heinze A, Horlick E, Malik I, Ray S, Zermansky A, Findling O, Windecker S, Meier B. Percutaneous closure of patent foramen ovale in migraine with aura, a randomized controlled trial. Eur Heart J. 2016 Jul 7;37(26):2029-36. doi: 10.1093/eurheartj/ehw027. Epub 2016 Feb 22. PMID: 26908949.
  168. Gupta VK. Botulinum toxin--a treatment for migraine? A systematic review. Pain Med. 2006 Sep-Oct;7(5):386-94. doi: 10.1111/j.1526-4637.2006.00216.x. PMID: 17014596.
  169. Gupta VK. ASD closure for migraine: is there a scientific basis? Eur Heart J. 2005 Jul;26(14):1446; author reply 1446-7. doi: 10.1093/eurheartj/ehi315. Epub 2005 May 4. PMID: 15872039.
  170. Herd CP, Tomlinson CL, Rick C, Scotton WJ, Edwards J, Ives NJ, Clarke CE, Sinclair AJ. Cochrane systematic review and meta-analysis of botulinum toxin for the prevention of migraine. BMJ Open. 2019 Jul 16;9(7):e027953. doi: 10.1136/bmjopen-2018-027953. PMID: 31315864; PMCID: PMC6661560.
  171. Herd CP, Tomlinson CL, Rick C, Scotton WJ, Edwards J, Ives N, Clarke CE, Sinclair A. Botulinum toxins for the prevention of migraine in adults. Cochrane Database Syst Rev. 2018 Jun 25;6(6):CD011616. doi: 10.1002/14651858.CD011616.pub2. PMID: 29939406; PMCID: PMC6513576.
  172. Castrillo Sanz A, Morollón Sánchez-Mateos N, Simonet Hernández C, Fernández Rodríguez B, Cerdán Santacruz D, Mendoza Rodríguez A, Rodríguez Sanz MF, Tabernero García C, Guerrero Becerra P, Ferrero Ros M, Duate García-Luis J. Experience with botulinum toxin in chronic migraine. Neurologia (Engl Ed). 2018 Oct;33(8):499-504. English, Spanish. doi: 10.1016/j.nrl.2016.09.004. Epub 2016 Oct 21. PMID: 27776965.
  173. Gupta VK. Nitric oxide and migraine: another systemic influence postulated to explain a lateralizing disorder. Eur J Neurol. 1996; 3:172-174.
  174. V M Fde L, W H. Relevance of excitable media theory and retinal spreading depression experiments in preclinical pharmacological research. Curr Neuropharmacol. 2014 Sep;12(5):413-33. doi: 10.2174/1570159X12666140630190800. PMID: 25426010; PMCID: PMC4243032.
  175. Martins-Ferreira H, Ribeiro LJ. Biphasic effects of gap junctional uncoupling agents on the propagation of retinal spreading depression. Braz J Med Biol Res. 1995 Sep;28(9):991-4. PMID: 8580888.
  176. Martins-Ferreira H. Spreading depression: a neurohumoral reaction. Braz J Med Biol Res. 1994 Apr;27(4):851-63. PMID: 8087091.
  177. Wang Y, Li Y, Wang M. Involvement of CGRP receptors in retinal spreading depression. Pharmacol Rep. 2016 Oct;68(5):935-8. doi: 10.1016/j.pharep.2016.05.001. Epub 2016 Jun 27. PMID: 27362770.
  178. Maranhão-Filho PA, Martins-Ferreira H, Vincent MB, Ribeiro LJ, Novis SA. Sumatriptan blocks spreading depression in isolated chick retina. Cephalalgia. 1997 Dec;17(8):822-5. doi: 10.1046/j.1468-2982.1997.1708822.x. PMID: 9453269.
  179. de Lima VMF, Hanke W. Reversibility of excitation waves in brain and heart and the energy of interfacial water. Can reversibility be explained by it? Prog Biophys Mol Biol. 2021 Jul;162:129-140. doi: 10.1016/j.pbiomolbio.2020.11.002. Epub 2020 Dec 3. PMID: 33279573.
  180. Evers S, Brockmann N, Summ O, Husstedt IW, Frese A. Primary headache and migraine in headache specialists - does personal history of doctors matter? Cephalalgia. 2020 Jan;40(1):96-106. doi: 10.1177/0333102419873671. Epub 2019 Sep 3. PMID: 31480900.
  181. Evans RW, Lipton RB, Silberstein SD. The prevalence of migraine in neurologists. Neurology. 2003 Nov 11;61(9):1271-2. doi: 10.1212/01.wnl.0000090628.46508.d4. PMID: 14610136.
  182. Noseda R, Burstein R. Migraine pathophysiology: anatomy of the trigeminovascular pathway and associated neurological symptoms, cortical spreading depression, sensitization, and modulation of pain. Pain. 2013 Dec;154 Suppl 1:S44-53. doi: 10.1016/j.pain.2013.07.021. Epub 2013 Jul 25. PMID: 23891892.
  183. Gupta VK. Brainstem activity in migraine: primary or secondary? Arch Neurol. 2006 Sep;63(9):1347. doi: 10.1001/archneur.63.9.1347-a. PMID: 16966528.
  184. Roque Bravo R, Faria AC, Brito-da-Costa AM, Carmo H, Mladěnka P, Dias da Silva D, Remião F, On Behalf Of The Oemonom Researchers. Cocaine: An Updated Overview on Chemistry, Detection, Biokinetics, and Pharmacotoxicological Aspects including Abuse Pattern. Toxins (Basel). 2022 Apr 13;14(4):278. doi: 10.3390/toxins14040278. PMID: 35448887; PMCID: PMC9032145.
  185. Farooque U, Okorie N, Kataria S, Shah SF, Bollampally VC. Cocaine-Induced Headache: A Review of Pathogenesis, Presentation, Diagnosis, and Management. Cureus. 2020 Aug 30;12(8):e10128. doi: 10.7759/cureus.10128. PMID: 33005542; PMCID: PMC7524019.
  186. Sutter FK, Helbig H. Familial retinal arteriolar tortuosity: a review. Surv Ophthalmol. 2003 May-Jun;48(3):245-55. doi: 10.1016/s0039-6257(03)00029-8. PMID: 12745002.
  187. Victor DI, Welch RB. Bilateral retinal hemorrhages and disk edema in migraine. Am J Ophthalmol. 1977 Oct;84(4):555-8. doi: 10.1016/0002-9394(77)90451-2. PMID: 910861.
  188. Broadway DC, Drance SM. Glaucoma and vasospasm. Br J Ophthalmol. 1998 Aug;82(8):862-70. doi: 10.1136/bjo.82.8.862. PMID: 9828767; PMCID: PMC1722701.
  189. Nicolela MT, Drance SM. Various glaucomatous optic nerve appearances: clinical correlations. Ophthalmology. 1996 Apr;103(4):640-9. doi: 10.1016/s0161-6420(96)30640-4. PMID: 8618765.
  190. Tenório LH, Santos AC, Câmara Neto JB, Amaral FJ, Passos VM, Lima AM, Brasileiro-Santos Mdo S. The influence of inspiratory muscle training on diaphragmatic mobility, pulmonary function and maximum respiratory pressures in morbidly obese individuals: a pilot study. Disabil Rehabil. 2013;35(22):1915-20. doi: 10.3109/09638288.2013.769635. Epub 2013 May 7. PMID: 23651130.
  191. Ramana RK, Sanagala T, Lichtenberg R. A new angle on the Angle of Louis. Congest Heart Fail. 2006 Jul-Aug;12(4):196-9. PMID: 16894277.
  192. Weiss KD, Kuriyan AE, Flynn HW Jr. Central retinal vein occlusion after prolonged vomiting and repeated valsalva maneuvers associated with gastroenteritis and dehydration. Ophthalmic Surg Lasers Imaging Retina. 2014 Apr 9;45 Online:e23-5. doi: 10.3928/23258160-20140331-03. PMID: 24702759.
  193. Tembl J, Lago A, Sevilla T, Solis P, Vilchez J. Migraine, patent foramen ovale and migraine triggers. J Headache Pain. 2007 Feb;8(1):7-12. doi: 10.1007/s10194-007-0359-x. Epub 2007 Feb 19. PMID: 17361381; PMCID: PMC3476121.
  194. Sevik MO, Çam F, Aykut A, Dericioğlu V, Şahin Ö. Choroidal vascularity index changes during the Valsalva manoeuvre in healthy volunteers. Ophthalmic Physiol Opt. 2022 Mar;42(2):367-375. doi: 10.1111/opo.12935. Epub 2021 Dec 16. PMID: 34913506.
  195. Vaghefi E, Shon C, Reading S, Sutherland T, Borges V, Phillips G, Niederer RL, Danesh-Meyer H. Intraocular pressure fluctuation during resistance exercise. BMJ Open Ophthalmol. 2021 May 13;6(1):e000723. doi: 10.1136/bmjophth-2021-000723. PMID: 34046525; PMCID: PMC8126276.
  196. Vieira GM, Oliveira HB, de Andrade DT, Bottaro M, Ritch R. Intraocular pressure variation during weight lifting. Arch Ophthalmol. 2006 Sep;124(9):1251-4. doi: 10.1001/archopht.124.9.1251. PMID: 16966619.
  197. Gupta VK. Reader response: Association of a cyclical migraine phenotype with phenotype with disease progression: A one-year time series analysis. Submitted 13 August 2022.
  198. Gupta VK. Ocular compression maneuver aborts benign cough-induced headache. Headache. 2005 May;45(5):612-4. doi: 10.1111/j.1526-4610.2005.05117_4.x. PMID: 15953285.
  199. Gupta VK. Is benign cough headache caused by intraocular haemodynamic aberration? Med Hypotheses. 2004;62(1):45-8. doi: 10.1016/s0306-9877(03)00298-6. PMID: 14729003.
  200. Coleman DJ, Trokel S. Direct-recorded intraocular pressure variations in a human subject. Arch Ophthalmol. 1969 Nov;82(5):637-40. doi: 10.1001/archopht.1969.00990020633011. PMID: 5357713.
  201. Ioannidis JP. Why most published research findings are false. PLoS Med. 2005 Aug;2(8):e124. doi: 10.1371/journal.pmed.0020124. Epub 2005 Aug 30. Erratum in: PLoS Med. 2022 Aug 25;19(8):e1004085. PMID: 16060722; PMCID: PMC1182327.
  202. Feinstein AR. "Clinical Judgment" revisited: the distraction of quantitative models. Ann Intern Med. 1994 May 1;120(9):799-805. doi: 10.7326/0003-4819-120-9-199405010-00012. PMID: 8147553.
  203. Hokenson RE, Short AK, Chen Y, Pham AL, Adams ET, Bolton JL, Swarup V, Gall CM, Baram TZ. Unexpected Role of Physiological Estrogen in Acute Stress-Induced Memory Deficits. J Neurosci. 2021 Jan 27;41(4):648-662. doi: 10.1523/JNEUROSCI.2146-20.2020. Epub 2020 Dec 1. PMID: 33262247; PMCID: PMC7842761.
  204. Schoech L, Allie K, Salvador P, Martinez M, Rivas E. Sex Differences in Thermal Comfort, Perception, Feeling, Stress and Focus During Exercise Hyperthermia. Percept Mot Skills. 2021 Jun;128(3):969-987. doi: 10.1177/00315125211002096. Epub 2021 Mar 17. PMID: 33730933.
  205. Celik F, Edipoglu IS. Evaluation of preoperative anxiety and fear of anesthesia using APAIS score. Eur J Med Res. 2018 Sep 11;23(1):41. doi: 10.1186/s40001-018-0339-4. PMID: 30205837; PMCID: PMC6131845.
  206. Byrd-Bredbenner C, Eck K, Quick V. GAD-7, GAD-2, and GAD-mini: Psychometric properties and norms of university students in the United States. Gen Hosp Psychiatry. 2021 Mar-Apr;69:61-66. doi: 10.1016/j.genhosppsych.2021.01.002. Epub 2021 Jan 9. PMID: 33571925.
  207. Zloto O, Skaat A, Fabian ID, Rosner M, Ziv H, Leshno A, Melamed S. The distribution of relaxin receptors in the anterior segment of primary open-angle glaucoma patients. Indian J Ophthalmol. 2020 Oct;68(10):2117-2120. doi: 10.4103/ijo.IJO_2008_19. PMID: 32971620; PMCID: PMC7728022.
  208. Celikbilek A, Sabah S, Tanik N, Ak H, Atalay T, Yilmaz N. Is serum S100B protein an useful biomarker in migraine? Neurol Sci. 2014 Aug;35(8):1197-201. doi: 10.1007/s10072-014-1679-7. Epub 2014 Feb 16. PMID: 24531979.
  209. Hampel U, Klonisch T, Sel S, Schulze U, Garreis F, Seitmann H, Zouboulis CC, Paulsen FP. Insulin-like factor 3 promotes wound healing at the ocular surface. Endocrinology. 2013 Jun;154(6):2034-45. doi: 10.1210/en.2012-2201. Epub 2013 Mar 28. Erratum in: Endocrinology. 2014 Jan;155(1):331. Garreis, Fabian [added]; Seitmann, Holger [added]; Zouboulis, Christos C [added]. PMID: 23539510.
  210. Goldsmith LT, Weiss G. Relaxin in human pregnancy. Ann N Y Acad Sci. 2009 Apr;1160:130-5. doi: 10.1111/j.1749-6632.2008.03800.x. PMID: 19416173; PMCID: PMC3856209.
  211. Tzourio C, El Amrani M, Robert L, Alpérovitch A. Serum elastase activity is elevated in migraine. Ann Neurol. 2000 May;47(5):648-51. PMID: 10805337.
  212. Pieretti S, Di Giannuario A, Di Giovannandrea R, Marzoli F, Piccaro G, Minosi P, Aloisi AM. Gender differences in pain and its relief. Ann Ist Super Sanita. 2016 Apr-Jun;52(2):184-9. doi: 10.4415/ANN_16_02_09. PMID: 27364392.
  213. Hu R, McDonough AA, Layton AT. Sex differences in solute and water handling in the human kidney: Modeling and functional implications. iScience. 2021 May 29;24(6):102667. doi: 10.1016/j.isci.2021.102667. PMID: 34169242; PMCID: PMC8209279.
  214. Taradaj K, Ginda T, Maciejewicz P, Suchonska B, Wielgos M, Kecik D, Kociszewska-Najman B. Does pregnancy influence eye parameters? Assessment of choroidal thickness using EDI-OCT before and after labour depending on the way of delivery method. Ginekol Pol. 2020;91(11):668-673. doi: 10.5603/GP.a2020.0137. PMID: 33301160.
  215. Roskal-Wałek J, Laudańska-Olszewska I, Biskup M, Gierada M, Odrobina D. Choroidal Thickness in Women with Uncomplicated Pregnancy: Literature Review. Biomed Res Int. 2017;2017:5694235. doi: 10.1155/2017/5694235. Epub 2017 Nov 9. PMID: 29250544; PMCID: PMC5700513.
  216. Jastaniah N, Sagim RA, Sanyour RM, Alamri DM, Bajandouh RH, Shaheen EA, Althubaiti A. A Retrospective Chart Review: The Prevalence of Hyponatremia Among Elderly Inpatients in a Tertiary Care Centre in Saudi Arabia. Cureus. 2022 Mar 8;14(3):e22960. doi: 10.7759/cureus.22960. PMID: 35411259; PMCID: PMC8989247.
  217. Filippatos TD, Makri A, Elisaf MS, Liamis G. Hyponatremia in the elderly: challenges and solutions. Clin Interv Aging. 2017 Nov 14;12:1957-1965. doi: 10.2147/CIA.S138535. PMID: 29180859; PMCID: PMC5694198.
  218. Dastiridou AI, Ginis HS, De Brouwere D, Tsilimbaris MK, Pallikaris IG. Ocular rigidity, ocular pulse amplitude, and pulsatile ocular blood flow: the effect of intraocular pressure. Invest Ophthalmol Vis Sci. 2009 Dec;50(12):5718-22. doi: 10.1167/iovs.09-3760. Epub 2009 Jul 15. PMID: 19608534.
  219. Pallikaris IG, Kymionis GD, Ginis HS, Kounis GA, Tsilimbaris MK. Ocular rigidity in living human eyes. Invest Ophthalmol Vis Sci. 2005 Feb;46(2):409-14. doi: 10.1167/iovs.04-0162. PMID: 15671262.
  220. Afridi S, Kaube H, Goadsby PJ. Occipital activation in glyceryl trinitrate induced migraine with visual aura. J Neurol Neurosurg Psychiatry. 2005 Aug;76(8):1158-60. doi: 10.1136/jnnp.2004.050633. PMID: 16024898; PMCID: PMC1739768.
  221. Ailani J. A Practical Approach to Autonomic Dysfunction in Patients with Headache. Curr Neurol Neurosci Rep. 2016 May;16(5):41. doi: 10.1007/s11910-016-0641-x. PMID: 27021770.
  222. Alkozi HA, Navarro G, Franco R, Pintor J. Melatonin and the control of intraocular pressure. Prog Retin Eye Res. 2020 Mar;75:100798. doi: 10.1016/j.preteyeres.2019.100798. Epub 2019 Sep 25. PMID: 31560946.
  223. Alkozi H, Sánchez-Naves J, de Lara MJ, Carracedo G, Fonseca B, Martinez-Aguila A, Pintor J. Elevated intraocular pressure increases melatonin levels in the aqueous humour. Acta Ophthalmol. 2017 May;95(3):e185-e189. doi: 10.1111/aos.13253. Epub 2016 Sep 6. PMID: 27595784.
  224. Barrachina-Esteve O, Hidalgo-Torrico I, Acero C, Aranceta S, Cánovas-Vergé D, Ribera G. Visual snow syndrome and its relationship with migraine. Neurologia 2021;S0213-4853(21)00112-2. [PMID: 34521544] [doi: 10.1016/j.nrl.2021.05.012]
  225. Birk S, Kruuse C, Petersen KA, Jonassen O, Tfelt-Hansen P, Olesen J. The phosphodiesterase 3 inhibitor cilostazol dilates large cerebral arteries in humans without affecting regional cerebral blood flow. J Cereb Blood Flow Metab. 2004 Dec;24(12):1352-8. doi: 10.1097/01.WCB.0000143536.22131.D7. PMID: 15625409.
  226. Butt JH, Rostrup E, Hansen AS, Lambertsen KL, Kruuse C. Induction of migraine-like headache, but not aura, by cilostazol in patients with migraine with aura. Brain. 2018 Oct 1;141(10):2943-2951. doi: 10.1093/brain/awy228. PMID: 30137217.
  227. Celikbilek A. Migraine symptoms and the role of autonomic dysfunction. Eur J Neurol. 2020 Dec;27(12):e97. doi: 10.1111/ene.14504. Epub 2020 Sep 21. PMID: 32888332.
  228. Christensen CE, Younis S, Lindberg U, de Koning P, Tolnai D, Paulson OB, Larsson HBW, Amin FM, Ashina M. Intradural artery dilation during experimentally induced migraine attacks. Pain. 2021 Jan;162(1):176-183. doi: 10.1097/j.pain.0000000000002008. PMID: 32701652.
  229. Cursiefen C, Wisse M, Cursiefen S, Jünemann A, Martus P, Korth M. Migraine and tension headache in high-pressure and normal-pressure glaucoma. Am J Ophthalmol. 2000 Jan;129(1):102-4. doi: 10.1016/s0002-9394(99)00289-5. PMID: 10653426.
  230. Falkenberg K, Bjerg HR, Olesen J. Subcutaneous sumatriptan reduces cilostazol induced headache in migraine patients. Cephalalgia. 2020 Jul;40(8):842-850. doi: 10.1177/0333102420915166. Epub 2020 Mar 26. PMID: 32216457.
  231. Fraser CL, Hepschke JL, Jenkins B, Prasad S. Migraine Aura: Pathophysiology, Mimics, and Treatment Options. Semin Neurol. 2019 Dec;39(6):739-748. doi: 10.1055/s-0039-1700525. Epub 2019 Dec 17. PMID: 31847045.
  232. Gupta VK. Reader Response: Blood-Brain Barrier Permeability in Patients With Reversible Cerebral Vasoconstriction Syndrome Assessed With Dynamic Contrast-Enhanced MRI. Neurology. 2022 Mar 1;98(9):382-383. doi: 10.1212/WNL.0000000000013318. PMID: 35228316.
  233. Gupta VK. Interatrial shunt-associated migraine: serendipity, empiricism, hope, or hype? Stroke. 2006 Sep;37(9):2212; author reply 2213. doi: 10.1161/01.STR.0000237167.80526.13. Epub 2006 Aug 10. PMID: 16902169.
  234. Gupta VK. Cortical spreading depression is neuroprotective: the challenge of basic sciences. Headache. 2005 Feb;45(2):177-8; author reply 178. doi: 10.1111/j.1526-4610.2005.05039_1.x. PMID: 15705129.
  235. Gupta VK. Migraine, epilepsy, and brain neuronal hyperexcitation. Headache. 2005 Jan;45(1):89; author reply 89-90. doi: 10.1111/j.1526-4610.2005.05019.x. PMID: 15663624.
  236. Gupta VK. Closure of ASD: what aggravates the migrainous diathesis? Eur Heart J. 2006 Jul;27(14):1756-7. doi: 10.1093/eurheartj/ehl070. Epub 2006 Jun 7. PMID: 16760211.
  237. Gupta VK. Does magnesium supplementation have any role in acute myocardial infarction? No. Cardiovasc Drugs Ther. 1996 Jul;10(3):303-5. doi: 10.1007/BF02627952. PMID: 8877071.
  238. Gupta VK. Patent foramen ovale/atrial septal defect closure and migraine: searching the rationale for the procedure. J Am Coll Cardiol. 2005 Aug 16;46(4):737-8; author reply 738-9. doi: 10.1016/j.jacc.2005.05.029. PMID: 16098448.
  239. Gupta VK. Clopidogrel and atrial shunt closure for migraine: why is migraine aggravated immediately? Heart 2005. Comment on: Wilmshurst. 2005;91(9):1173-1175.[PMID: 16103551] [doi: 10.1136/hrt.2004.047746] Available at: https://heart.bmj.com/content/91/9/1173.responses#clopidogrel-and-atrial-shunt-closure-for-migraine-why-is-migraine-aggravated-immediately
  240. Gupta VK. Glyceryl trinitrate and migraine: nitric oxide donor precipitating and aborting migrainous aura. J Neurol Neurosurg Psychiatry 2005.
  241. Harris A, Kagemann L, Ehrlich R, Ehrlich Y, López CR, Purvin VA. The effect of sildenafil on ocular blood flow. Br J Ophthalmol. 2008 Apr;92(4):469-73. doi: 10.1136/bjo.2007.131789. PMID: 18369062.
  242. Hickner J. New-and surprising-ways to approach migraine pain. J Fam Pract. 2022 Jun;71(5):198-218. doi: 10.12788/jfp.0432. PMID: 35776873.
  243. Hodak J, Fischer U, Bassetti CLA, Schankin CJ. Episodic Visual Snow Associated With Migraine Attacks. JAMA Neurol. 2020 Mar 1;77(3):392-393. doi: 10.1001/jamaneurol.2019.4050. PMID: 31764944; PMCID: PMC6902200.
  244. Hwang DJ, Shin JY, Yu HG. Oral Administration of Cilostazol Increases Ocular Blood Flow in Patients with Diabetic Retinopathy. Korean J Ophthalmol. 2017 Apr;31(2):123-131. doi: 10.3341/kjo.2017.31.2.123. Epub 2017 Mar 21. PMID: 28367040; PMCID: PMC5368085.
  245. Iser C, Arca K. Headache and Autonomic Dysfunction: a Review. Curr Neurol Neurosci Rep. 2022 Oct;22(10):625-634. doi: 10.1007/s11910-022-01225-3. Epub 2022 Aug 22. PMID: 35994191.
  246. Katz BJ. Put a Drop of Timolol Into Each Eye and Call Me in the Morning. JAMA Ophthalmol. 2020 Nov 1;138(11):1166-1167. doi: 10.1001/jamaophthalmol.2020.3837. PMID: 33001150.
  247. Khawaja AP, Chan MP, Broadway DC, Garway-Heath DF, Luben R, Yip JL, Hayat S, Wareham NJ, Khaw KT, Foster PJ. Systemic medication and intraocular pressure in a British population: the EPIC-Norfolk Eye Study. Ophthalmology. 2014 Aug;121(8):1501-7. doi: 10.1016/j.ophtha.2014.02.009. Epub 2014 Apr 2. PMID: 24702754; PMCID: PMC4109027.
  248. Koksal M, Ozdemir H, Kargi S, Yesilli C, Tomaç S, Mahmutyazicioglu K, Mungan A. The effects of sildenafil on ocular blood flow. Acta Ophthalmol Scand. 2005 Jun;83(3):355-9. doi: 10.1111/j.1600-0420.2005.00422.x. PMID: 15948790.
  249. Panicker G, Kaliaperumal S, Narayan S, Mani M. Glaucoma and optical coherence tomography changes in migraine: A comparative cross-sectional study. Indian J Ophthalmol. 2021 Dec;69(12):3546-3551. doi: 10.4103/ijo.IJO_375_21. PMID: 34826993; PMCID: PMC8837329.
  250. Plaisier E, Ronco P. COL4A1-Related Disorders. 2009 Jun 25 [updated 2016 Jul 7]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2023. PMID: 20301768.
  251. Rangel YM, Karikó K, Harris VA, Duvall ME, Welsh FA. Dose-dependent induction of mRNAs encoding brain-derived neurotrophic factor and heat-shock protein-72 after cortical spreading depression in the rat. Brain Res Mol Brain Res. 2001 Mar 31;88(1-2):103-12. doi: 10.1016/s0169-328x(01)00037-7. PMID: 11295236.
  252. Vance SK, Imamura Y, Freund KB. The effects of sildenafil citrate on choroidal thickness as determined by enhanced depth imaging optical coherence tomography. Retina. 2011 Feb;31(2):332-5. doi: 10.1097/IAE.0b013e3181eef0ae. PMID: 20975620.
  253. P Vilela MA, Colossi CG, Freitas HP, Valle GD, Pellanda LC. Ocular Alterations Associated with Primary Congenital Heart Disease - A Cross-sectional Study. Middle East Afr J Ophthalmol. 2020 Apr 29;27(1):28-33. doi: 10.4103/meajo.MEAJO_89_19. PMID: 32549721; PMCID: PMC7276169.
  254. Wang JJ, Mitchell P, Smith W. Is there an association between migraine headache and open-angle glaucoma? Findings from the Blue Mountains Eye Study. Ophthalmology. 1997 Oct;104(10):1714-9. doi: 10.1016/s0161-6420(97)30075-x. PMID: 9331214.
  255. Wu F, Zhao Y, Zhang H. Ocular Autonomic Nervous System: An Update from Anatomy to Physiological Functions. Vision (Basel). 2022 Jan 14;6(1):6. doi: 10.3390/vision6010006. PMID: 35076641; PMCID: PMC8788436. 

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