Abstract

Research Article

The turing machine theory for some spinal cord and brain condition, A toxicological - antidotic depurative approach

Mauro Luisetto*, Behzad Nili Ahmadabadi, Ahmed Yesvi Rafa, Ram Kumar Sahu, Luca Cabianca, Ghulam Rasool Mashori and Farhan Ahmad Khan

Published: 31 July, 2019 | Volume 3 - Issue 2 | Pages: 102-134

Aim of this work is to produce a general theory related an new depurative strategy to be devalued for reduce or delay some spinal cord and brain degenerative and inflammatory chronic disease or acute traumatic condition. It is used and informatics approach in order to set correct the problem and the process. Scope of this project is to submit to the researcher a new therapeutic strategy (under a depurative- toxicological-pharmacological) in this complex kind of disease. A Turing machine theory say us a method to TRASLATE the need of a strategy in a practical hypotesys of work. A global conceptual map can help in this field.

Read Full Article HTML DOI: 10.29328/journal.jnnd.1001023 Cite this Article Read Full Article PDF

Keywords:

Spinal cord; Brain; Degenerative disease; Trauma; Immune disease; Neurotoxicity pathology; Toxicology; Pharmacology; Depurative methods; Informatics; Algorytms

References

  1. Mauro L, Behzad NA, Nilesh MM, Ghulam RM, Ram KS, et al. Amyotrophic Lateral Sclerosis and Endogenous-Esogenous Toxicological Movens: New Model to Verify Other Pharmacological Strategies. J of Pharmacol & Clin Res. 2018; 6: 555690.
  2. Luisetto M, Almukhtar N, Rafa AY, Ahmadabadi BN, Mashori GR, et al. Role of plants, environmental toxins and physical neurotoxicological factors in Amyotrophic lateral sclerosis, AD and other Neuro-degenerative Diseases.
  3. Luisetto M, Almukhtar N, Ahmadabadi BN, Hamid GA, Mashori GR, et al. Clinical Pathology & Research Journal Endogenus Toxicology: Modern Physio- Pathological Aspects and Relationship with New Therapeutic Strategies. An Integrative Discipline Incorporating Concepts from different Research Discipline like Biochemistry, Pharmacology and Toxicology. Clin Pathol.
  4. Alabdali A, Al-Ayadhi L, El-Ansary A. A key role for an impaired detoxification mechanism in the etiology and severity of autism spectrum disorders. Behav Brain Funct. 2014; 10: 14. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/24776096
  5. Nedergaard M, Steven A. Brain Drain Goldman Sci Am. 2016; 314: 44–49.
  6. Dringen R, Pawlowski PG, Hirrlinger J. Peroxide detoxification by brain cells. J Neurosci Res. 2005; 79: 157-165.
  7. Lee H, XieL, Yu M, Kang H, Feng T, et al. The Effect of Body Posture on Brain Glymphatic Transport. J Neurosci. 2015; 35: 11034–11044. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/26245965
  8. Xu J, Huang G, Zhang K, Sun F, Xu T, et al. Activation in Astrocytes Contributes to Spinal Cord Ischemic Tolerance Induced by Hyperbaric Oxygen Preconditioning. J Neurotrauma. 2014; 31: 1343–1353. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/24716787
  9. Hodges GR, Watanabe I. Chemical injury of the spinal cord of the rabbit after intracisternal injection of gentamicin: an ultrastructural study. J Neuropathol Exp Neurol. 1980; 39: 452-75. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/6894308
  10. Sundaram RK, Kasinathan C, Stein S, Sundaram P. Detoxification depot for beta-amyloid peptides. Curr Alzheimer Res. 2008; 5: 26-32. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/18288928
  11. Marsala M, Malmberg AB, Yaksh TL. The spinal loop dialysis catheter: characterization of use in the unanesthetized rat. J Neurosci Methods. 1995; 62: 43-53. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/8750084
  12. Hong Y, Palaksha KJ, Park K, Park S, Kim HD, et al. Melatonin plus exercise-based neurorehabilitative therapy for spinal cord injury. J. Pineal Res. 2010; 49: 201–209. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/20626592
  13. Rathore KI, Kerr BJ, Redensek A, López-Vales R, Jeong SY, et al. Ceruloplasmin protects injured spinal cord from iron-mediated oxidative damage. J Neurosci. 2008; 28: 12736 –12747. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/19036966
  14. Rajiv R. Ratan, Mark Noble. Novel multi-modal strategies to promote brain and spinal cord injury recovery. Stroke. 2009; 40: S130–S132. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/19064774
  15. Goetz T, Romero-Sierra C, Ethier R, Henriksen RN. Modeling of therapeutic dialysis of cerebrospinal fluid by epidural cooling in spinal cord injuries. Journal of Neurotrauma. 1988; 5: 139-150. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/3225857
  16. Freund P, Curt A, Friston K, Thompson A. Tracking Changes following Spinal Cord Injury: Insights from Neuroimaging. Neuroscientist. 2013; 19: 116–128. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/22730072
  17. Raisman G. A promising therapeutic approach to spinal cord repair. J R Soc Med. 2003; 96: 0141-0768. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/12782687
  18. Camandola S, Mattson MP. Brain metabolism in health, aging, and neuro-degeneration. BMC Neurol. 2017; 36: 1474-1492. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/27875990
  19. Farron L.McIntee, PatriziaGiannoni, StevenBlais, GeorgeSommer, Thomas A Neubert, et al. Invivo Differential Brain Clearance and Catabolism of Monomeric and Oligomeric Alzheimer’s Abprotein.
  20. Walker S. Jackson. Review Selective vulnerability to neuro-degenerative disease: the curious case of Prion Protein. Disease Models & Mechanisms. 2014; 7: 21-29.
  21. Marsala M, Sorkin LS, Yaksh TL. Transient Spinal Ischemia in Rat: Characterization of Spinal Cord Blood Flow, Extracellular Amino Acid Release, and Concurrent Histopathological Damage. J Cereb Blood Flow Metab. 1994; 14: 604-614. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/8014207
  22. Sakkaa L, Coll G, Chazala J. Anatomy and physiology of cerebro-spinal fluid. Eur Ann Otorhinolaryngol Head Neck Dis. 2011; 128: 309-316. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/22100360
  23. Tarasoff-Conway JM, Carare RO, Osorio RS, Glodzik L, Butler T, et al. Clearance systems in the brain-implications for Alzheimer disease. Nat Rev Neurol. 2015; 11: 457-470. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/26195256
  24. Thompson SJ, Bernards CM. Barrier Properties of the Spinal Meninges Are Markedly Decreased by Freezing Meningeal Tissues.
  25. Weller J, Budson A. Current understanding of Alzheimer’s disease diagnosis and treatment. 2018.
  26. Nalivaeva NN, Turner AJ. Targeting amyloid clearance in Alzheimer’s disease as a therapeutic strategy. Br J Pharmacol. 2019. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/30710367
  27. Ahmad MH, Fatima M, Mondal AC. Influence of microglia and astrocyte activation in the neuroinflammatory pathogenesis of Alzheimer’s disease: Rational insights for the therapeutic approaches. J Clin Neurosci. 2019. 59: 6-11. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/30385170
  28. Malik GA, Roberts NP. Treatments in Alzheimer’s disease. J Neurol. 2017; 264: 416–418.
  29. Thelin EP, Nelson DE, Ghatan PH, Bellander BM. Microdialysis monitoring of CSF parameters in severe traumatic brain injury patients: a novel approach. Frontiers in neurology. 2014. 5: 159. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/25228896
  30. Ågren-Wilsson A, Roslin M, Eklund A, Koskinen L, Bergenheim A, et al. Intracerebral microdialysis and CSF hydrodynamics in idiopathic adult hydrocephalus syndrome. J Neurol Neurosurg Psychiatry. 2003; 74: 217–221. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/12531954
  31. Shulyakov AV, Benour M, Del Bigio MR. Surface dialysis after experimental brain injury: modification of edema fluid flow in the rat model Laboratory investigation. 2008; 109.
  32. Mayer F, Mayer N, Chinn L, Pinsonneault RL, Kroetz D, et al. Evolutionary conservation of vertebrate blood-brain barrier chemoprotective mechanisms in Drosophila. J Neurosci. 2009; 29: 3538–3550. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/19295159
  33. Bueno D, Garcia-Fernàndez J. Evolutionary development of embryonic cerebrospinal fluid composition and regulation: an open research field with implications for brain development and function. Fluids and Barriers of the CNS. 2016; 13: 5. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/26979569
  34. Park M, Moon WJ. Structural MR Imaging in the Diagnosis of Alzheimer’s disease and Other Neurodegenerative Dementia: Current Imaging Approach and Future Perspectives. J Radiol. 2016; 17: 827-845. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/27833399
  35. Sundaram RK, Kasinathan C, Stein S, Sundaram P. Novel Detox Gel Depot sequesters β-Amyloid Peptides in a mouse model of Alzheimer’s disease. Int J Pept Res Ther. 2012; 18: 99-106.

Figures:

Figure 1

Figure 1

Figure 1

Figure 2

Figure 1

Figure 3

Figure 1

Figure 4

Figure 1

Figure 5

Figure 1

Figure 6

Figure 1

Figure 7

Figure 1

Figure 8

Figure 1

Figure 9

Figure 1

Figure 10

Figure 1

Figure 11

Figure 1

Figure 12

Similar Articles

Recently Viewed

  • Environmental Factors Affecting the Concentration of DNA in Blood and Saliva Stains: A Review
    Divya Khorwal*, GK Mathur, Umema Ahmed and SS Daga Divya Khorwal*, GK Mathur, Umema Ahmed, SS Daga. Environmental Factors Affecting the Concentration of DNA in Blood and Saliva Stains: A Review. J Forensic Sci Res. 2024: doi: 10.29328/journal.jfsr.1001057; 8: 009-015
  • Why Down-managing Backlog Forensic DNA Case Entries Matters
    JH Smith* and JS Horne JH Smith*, JS Horne. Why Down-managing Backlog Forensic DNA Case Entries Matters. J Forensic Sci Res. 2024: doi: 10.29328/journal.jfsr.1001056; 8: 001-008
  • Scintigraphic non-invasive diagnosis of amyloid cardiomyopathy
    Laroussi Mohamed-Salem*, Tomás E Rodríguez-Locarno, Tatiana Moreno-Monsalve, Isabel Castellón-Sánchez, José F Contreras-Gutiérrez and Antonia Claver-Valderas Laroussi Mohamed-Salem*,Tomás E Rodríguez-Locarno,Tatiana Moreno-Monsalve,Isabel Castellón-Sánchez,José F Contreras-Gutiérrez ,Antonia Claver-Valderas. Scintigraphic non-invasive diagnosis of amyloid cardiomyopathy. J Cardiol Cardiovasc Med. 2019: doi: 10.29328/journal.jccm.1001058; 4: 156-158
  • Anomalies of coronary artery origin: About two cases
    Dioum M*, Sarr EM, Manga S, Mingou JS, Diack A, Diop AD, Bindia D, Diagne PA, Sarr AN and Diop IB Dioum M*,Sarr EM,Manga S,Mingou JS,Diack A,Diop AD,Bindia D,Diagne PA,Sarr AN,Diop IB. Anomalies of coronary artery origin: About two cases. J Cardiol Cardiovasc Med. 2019: doi: 10.29328/journal.jccm.1001051; 4: 117-119
  • Late discover of a traumatic cardiac injury: Case report
    Benlafqih C, Bouhdadi H*, Bakkali A, Rhissassi J, Sayah R and Laaroussi M Benlafqih C,Bouhdadi H*,Bakkali A,Rhissassi J,Sayah R,Laaroussi M. Late discover of a traumatic cardiac injury: Case report. J Cardiol Cardiovasc Med. 2019: doi: 10.29328/journal.jccm.1001048; 4: 100-102

Read More

Most Viewed

Read More

Help ?