Abstract

Review Article

Neurobiology of Common Sleep Disorders

Zhao Liu*, Abdullah Tolaymat and Sreenivas K Avula

Published: 14 August, 2018 | Volume 2 - Issue 2 | Pages: 039-046

Sleep disorders in human are common and detrimental to general health of all age groups. While the neurobiological mechanisms of sleep disorders are not yet fully understood, recent advances in research on the sleep-wake regulation mechanism, genetic and epigenetic factors, cognitive, emotional and physiological changes related to sleep have shed light on the mechanistic basis of sleep disorders. Over the past two decades, studies in Drosophila have yielded new insights into basic questions regarding sleep function and regulation. More recently, powerful genetic approaches in the fly have been applied toward studying primary human sleep disorders and other disorders associated with dysregulated sleep. In this review, we discussed recent advances in neurobiology of sleep-wave cycle and common sleep disorders. Understanding these mechanisms are important in the diagnosis, treatment and prevention of these common disorders.

Read Full Article HTML DOI: 10.29328/journal.jnnd.1001013 Cite this Article Read Full Article PDF

Keywords:

Sleep disorder; Insomnia; Hypersomnia; Parasomnia; Circadian Rhythms; Sleep-related movement disorders; Narcolepsy; Circadian rhythm disorder; Drosophilae; Fruit fly; Circadian gene period

References

  1. Jones BE. From waking to sleeping: neuronal and chemical substrates. Trends in Pharmacol Sci. 2005; 26: 578-586. Ref.: https://tinyurl.com/yc9pwoy4
  2. Tolaymat A, Liu Z. Sleep disorders in childhood neurological diseases. Children (Basel). 2017; 4: 84-98. Ref.: https://tinyurl.com/y9rvrpd7
  3. Brown RE, Basheer R, McKenna JT, Strecker RE, McCarley RW. Control of sleep and wakefulness. Physiol Rev. 2012: 92: 1087-1187. Ref.: https://tinyurl.com/yb6x7cu9
  4. Schwartz MD, Kliduff TS. The neurobiology of sleep and wakefulness. Psychiatr Clin North Am. 2015: 38: 615-644. Ref.: https://tinyurl.com/yd2kzpq3
  5. Hendricks JC, Kirk D, Pancheri K, Miller MS, Pack AI. Modafinil maintains waking in the fruit fly drosophila melanogaster. Sleep. 200; 26: 139-146. Ref.: https://tinyurl.com/yakzxkqd
  6. Wager-Smith K, Kay SA. Circadian rhythm genetics: From flies to mice to humans. Nature Genetics. 2000; 26: 23-27. Ref.: https://tinyurl.com/ybbao8hq
  7. Herber R, Hill SL, Holladay C, Biesiadecki M, Tononi G, et al. Sleep homeostasis in Drosophila melangaster. Sleep. 2004; 27: 628-639. Ref.: https://tinyurl.com/y7zaeruy
  8. Cirelli C. The genetic and molecular regulation of sleep: From fruit flies to humans. Nat Rev Neurosci. 2009; 10: 549-560. Ref.: https://tinyurl.com/yalawocu
  9. Lamberg L. Manual updates sleep disorder diagnoses. Psychiatric news. 2014.
  10. Roth T. Insomnia: Definition, prevalence, etiology, and consequences. J Clin Sleep Med. 2007; 3: 7-10. Ref.: https://tinyurl.com/ybmwegft
  11. Feige B, Al-Shajlawi A, Nisseb C, Voderholzer U, Hornyak M, et al. Does REM sleep contribute to subjective wake time in primary insomnia? A comparison of polysomnographic and subjective sleep in 100 patients. J Sleep Res. 2008; 7: 180-190. Ref.: https://tinyurl.com/y8by6557
  12. Wing YK, Zhang J, Lam SO, Li SX, Lai KY, et al. Familial aggregation and heritability of insomnia in a community-based study. Sleep Med. 2012; 13: 985-990. Ref.: https://tinyurl.com/yau9eqlt
  13. Barclay NL Eley TC, Buysse DJ, Archer SN, Gregory AM. Diurnal preference and sleep quality: same genes? A study of young adult twins. Chronobiol Int. 2010; 27: 278-296. Ref.: https://tinyurl.com/ycnvhjpc
  14. Josephs KA, Silber MH, Fealey RD, Nippoldt TB, Auge RG, et al. Neurophysiologic studies in Morvan syndrome. J Clin Neurophysiol. 2004; 21: 440-445. Ref.: https://tinyurl.com/y75qzz5s
  15. Serretti A, Benedetti F, Mandelli L, Lorenzi C, Pirovano A, et al. Genetic dissection of psychopathological symptoms: insomnia in mood disorders and CLOCK gene polymorphism. Am J Med Genet B Neuropsychiatr Genet, 2003; 121: 35-38. Ref.: https://tinyurl.com/yanatexl
  16. Buhr A, Bianchi MT, Baur R, Courtet P, Pignay V, et al. Functional characterization of the new human GABA(A) receptor mutation beta3(R192H). Hum Genet. 2002; 111: 154-160. Ref.: https://tinyurl.com/yauwaq5q
  17. Deuschle M, Schredl M, Schilling C, Wust S, Frank J, et al. Association between a serotonin transporter length polymorphism and primary insomnia. Sleep. 2010; 33: 343-347. Ref.: https://tinyurl.com/yaq6ytnc
  18. Barclay NL, Gregory AM. Quantitative genetic research on sleep: a review of normal sleep, sleep disturbances and associated emotional, behavioral and health-related difficulties. Sleep Med Rev. 2013; 17: 29-40. Ref.: https://tinyurl.com/y9p54kft
  19. Riemann D, Spiegelhalder K, Feige B, Voderholzer U, Berger M, et al. The hyperarousal model of insomnia: a review of the concept and its evidence. Sleep Med Rev. 2010; 14: 19-31. Ref.: https://tinyurl.com/y8b7nbd2
  20. Longstreth WT, Koepsell TD, Ton TG, Hendrickson AF, Van Bell B. The epidemiology of narcolepsy. Sleep. 2007; 30: 13-26. Ref.: https://tinyurl.com/yb94qq9m
  21. Khatami R, Maret S, Werth E, Retey J, Schmid D, et al. Monozygotic twins concordant for narcolepsy-cataplexy without any detectable abnormality in the hypocretin (orexin) pathway. Lancet. 2004; 363: 1199-1200. Ref.: https://tinyurl.com/ydgp3r9e
  22. Mignot E. Genetic and familial aspects of narcolepsy. Neurology. 1998; 50: 16-22. Ref.: https://tinyurl.com/y9vzmget
  23. Liu Z, Tolarmat A, Sreenivas KA. Neurobiology of narcolepsy. J Sleep Med & disorders. 2018; 5: 1093-1098.
  24. Konopka R, Pittendrigh C, Orr D. Reciprocal behavior associated with altered homeostasis and photosensitivity of Drosophila clock mutants. J Neurogenet. 1989; 6: 1-10. Ref.: https://tinyurl.com/yakfvdms
  25. Zhang Y, Ling Y, Yuan C, Dubruille R, Emery P. A role for Drosophila ATX2 in activation of PER translation and circadian behavior. Science. 2013; 340: 879-882. Ref.: https://tinyurl.com/ydz2tafk
  26. Chatterjee A. Hardin P. E. Time to taste: circadian clock function in the Drosophila gustatory system. Fly. 2010; 4: 283-287. Ref.: https://tinyurl.com/y9f7pzu3
  27. Karpowicz P, Zhang Y, Hogenesch JB, Emery P, Perrimon N. The circadian clock gates the intestinal stem cell regenerative state. Cell Reports. 2013; 4: 996-1004. Ref.: https://tinyurl.com/ycv4v3k6
  28. Konopka RJ. Benzer S. Clock mutants of Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America. 1971; 68: 2112-2116. Ref.: https://tinyurl.com/ybgkrkev
  29. Fan JY, Agyekum B, Venkatesan Y, Hall DR, Keightley A, et al. Noncanonical FK506-binding protein BDBT binds DBT to enhance its circadian function and forms foci at night. Neuron. 2013; 80: 984-996. Ref.: https://tinyurl.com/y94vj363
  30. Tei H, Okamura H, Shigeyoshi Y, Fukuhara C, Ozawa R, et al. Circadian oscillation of a mammalian homologue of the Drosophila period gene. Nature. 1997; 389: 512-516. Ref.: https://tinyurl.com/yck54vy2
  31. Dubowy C. Sehgal A. Circadian rhythms and sleep in Drosophila melanogaster. Genetics. 2017; 205: 1373-1397. Ref.: https://tinyurl.com/yaax9ztv
  32. Yeh P, Walters AS, Tsuang JW. A comprehensive overview on its epidemiology, risk factors and treatment. Subst Use Misuse. 2011; 47: 9-10.
  33. Sehgal A. Mignot E. Genetics of sleep and sleep disorders. Cell. 2011; 146: 194-207. Ref.: https://tinyurl.com/y7guppqa
  34. Yang Q, Li L, Chen Q, Foldvary-Schaefer N, Ondo WG, et al. Association studies of variants in MEIS1, BTBD9, and MAP2K5/SKOR1 with restless legs syndrome in a US population. Sleep Med. 2011; 12: 800-804. Ref.: https://tinyurl.com/ycq99qdc
  35. Freeman A, Pranski E, Miller RD, Radmard S, Bernhard D, et al. Strong fragmentation and motor restless in Drosohilia model of Restless legs syndrome. Curr Biol, 2012; 22: 1142-1148. Ref.: https://tinyurl.com/y8tx33r5
  36. Michaud M, Lavigne G, Dsaulels A, Poirier G, Montplaisir J. Effects of immobility on sensory and motor symptoms of restless legs syndromee. J Mov Dis Soc. 2002; 17: 112-115. Ref.: https://tinyurl.com/ycjmzm95
  37. Ferre S, Quiroz C, Guitart X, Rea W, Seyedian A, et al. Pivotal role of adenosine neurotransmittion in restless legs syndrome. Front Neurosci. 2018; 8: 722-736. Ref.: https://tinyurl.com/yaep4ymv

Similar Articles

Recently Viewed

Read More

Most Viewed

Read More

Help ?